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Page 1
iRhom2 promotes lupus nephritis through TNF-α and EGFR signaling.
Qing X, Chinenov Y, Redecha P, Madaio M, Roelofs JJ, Farber G, Issuree PD, Donlin L, Mcllwain DR, Mak TW, Blobel CP, Salmon JE. Qing X, et al. Among authors: donlin l. J Clin Invest. 2018 Apr 2;128(4):1397-1412. doi: 10.1172/JCI97650. Epub 2018 Mar 5. J Clin Invest. 2018. PMID: 29369823 Free PMC article.
Machine learning identification of thresholds to discriminate osteoarthritis and rheumatoid arthritis synovial inflammation.
Mehta B, Goodman S, DiCarlo E, Jannat-Khah D, Gibbons JAB, Otero M, Donlin L, Pannellini T, Robinson WH, Sculco P, Figgie M, Rodriguez J, Kirschmann JM, Thompson J, Slater D, Frezza D, Xu Z, Wang F, Orange DE. Mehta B, et al. Among authors: donlin l. Arthritis Res Ther. 2023 Mar 2;25(1):31. doi: 10.1186/s13075-023-03008-8. Arthritis Res Ther. 2023. PMID: 36864474 Free PMC article.
Publisher Correction: Interferon subverts an AHR-JUN axis to promote CXCL13+ T cells in lupus.
Law C, Wacleche VS, Cao Y, Pillai A, Sowerby J, Hancock B, Horisberger A, Bracero S, Skidanova V, Li Z, Adejoorin I, Dillon E, Benque IJ, Nunez DP, Simmons DP, Keegan J, Chen L, Baker T, Brohawn PZ, Al-Mossawi H, Hao LY, Jones B, Rao N, Qu Y, Alves SE; Accelerating Medicines Partnership: RA/SLE Network; Jonsson AH, Shaw KS, Vleugels RA, Massarotti E, Costenbader KH, Brenner MB, Lederer JA, Hultquist JF, Choi J, Rao DA. Law C, et al. Nature. 2024 Aug;632(8025):E6. doi: 10.1038/s41586-024-07845-8. Nature. 2024. PMID: 39060417 No abstract available.
Dynamic regulatory elements in single-cell multimodal data implicate key immune cell states enriched for autoimmune disease heritability.
Gupta A, Weinand K, Nathan A, Sakaue S, Zhang MJ; Accelerating Medicines Partnership RA/SLE Program and Network; Donlin L, Wei K, Price AL, Amariuta T, Raychaudhuri S. Gupta A, et al. Among authors: donlin l. Nat Genet. 2023 Dec;55(12):2200-2210. doi: 10.1038/s41588-023-01577-7. Epub 2023 Nov 30. Nat Genet. 2023. PMID: 38036783 Free PMC article.
Interferon subverts an AHR-JUN axis to promote CXCL13+ T cells in lupus.
Law C, Wacleche VS, Cao Y, Pillai A, Sowerby J, Hancock B, Horisberger A, Bracero S, Skidanova V, Li Z, Adejoorin I, Dillon E, Benque IJ, Nunez DP, Simmons DP, Keegan J, Chen L, Baker T, Brohawn PZ, Al-Mossawi H, Hao LY, Jones B, Rao N, Qu Y, Alves SE; Accelerating Medicines Partnership: RA/SLE Network; Jonsson AH, Shaw KS, Vleugels RA, Massarotti E, Costenbader KH, Brenner MB, Lederer JA, Hultquist JF, Choi J, Rao DA. Law C, et al. Nature. 2024 Jul;631(8022):857-866. doi: 10.1038/s41586-024-07627-2. Epub 2024 Jul 10. Nature. 2024. PMID: 38987586
Tissue-specific enhancer-gene maps from multimodal single-cell data identify causal disease alleles.
Sakaue S, Weinand K, Isaac S, Dey KK, Jagadeesh K, Kanai M, Watts GFM, Zhu Z; Accelerating Medicines Partnership® RA/SLE Program and Network; Brenner MB, McDavid A, Donlin LT, Wei K, Price AL, Raychaudhuri S. Sakaue S, et al. Among authors: donlin lt. Nat Genet. 2024 Apr;56(4):615-626. doi: 10.1038/s41588-024-01682-1. Epub 2024 Apr 9. Nat Genet. 2024. PMID: 38594305 Free PMC article.
Mapping the dynamic genetic regulatory architecture of HLA genes at single-cell resolution.
Kang JB, Shen AZ, Sakaue S, Luo Y, Gurajala S, Nathan A, Rumker L, Aguiar VRC, Valencia C, Lagattuta K, Zhang F, Jonsson AH, Yazar S, Alquicira-Hernandez J, Khalili H, Ananthakrishnan AN, Jagadeesh K, Dey K; Accelerating Medicines Partnership Program: Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Network; Daly MJ, Xavier RJ, Donlin LT, Anolik JH, Powell JE, Rao DA, Brenner MB, Gutierrez-Arcelus M, Raychaudhuri S. Kang JB, et al. Among authors: donlin lt. medRxiv [Preprint]. 2023 Mar 20:2023.03.14.23287257. doi: 10.1101/2023.03.14.23287257. medRxiv. 2023. Update in: Nat Genet. 2023 Dec;55(12):2255-2268. doi: 10.1038/s41588-023-01586-6 PMID: 36993194 Free PMC article. Updated. Preprint.
Deep immunophenotyping reveals circulating activated lymphocytes in individuals at risk for rheumatoid arthritis.
Inamo J, Keegan J, Griffith A, Ghosh T, Horisberger A, Howard K, Pulford J, Murzin E, Hancock B, Jonsson AH, Seifert J, Feser ML, Norris JM, Cao Y, Apruzzese W, Louis Bridges S, Bykerk V, Goodman S, Donlin L, Firestein GS, Perlman H, Bathon JM, Hughes LB, Tabechian D, Filer A, Pitzalis C, Anolik JH, Moreland L, Guthridge JM, James JA, Brenner MB, Raychaudhuri S, Sparks JA; Accelerating Medicines Partnership RA/SLE Network; Michael Holers V, Deane KD, Lederer JA, Rao DA, Zhang F. Inamo J, et al. Among authors: donlin l. bioRxiv [Preprint]. 2023 Jul 4:2023.07.03.547507. doi: 10.1101/2023.07.03.547507. bioRxiv. 2023. PMID: 37461737 Free PMC article. Preprint.
Associations Between Rheumatoid Arthritis Clinical Factors and Synovial Cell Types and States.
Weisenfeld D, Zhang F, Donlin L, Jonsson AH, Apruzzese W, Campbell D; Accelerating Medicines Partnership Program: RA/SLE Network; Rao DA, Wei K, Holers VM, Gravallese E, Moreland L, Goodman S, Brenner M, Raychaudhuri S, Filer A, Anolik J, Bykerk V, Liao KP. Weisenfeld D, et al. Among authors: donlin l. Arthritis Rheumatol. 2024 Mar;76(3):356-362. doi: 10.1002/art.42726. Epub 2024 Jan 19. Arthritis Rheumatol. 2024. PMID: 37791989
Regulation of type I interferon responses.
Ivashkiv LB, Donlin LT. Ivashkiv LB, et al. Nat Rev Immunol. 2014 Jan;14(1):36-49. doi: 10.1038/nri3581. Nat Rev Immunol. 2014. PMID: 24362405 Free PMC article. Review.
66 results