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The antimicrobial peptide SAAP-148 combats drug-resistant bacteria and biofilms.
de Breij A, Riool M, Cordfunke RA, Malanovic N, de Boer L, Koning RI, Ravensbergen E, Franken M, van der Heijde T, Boekema BK, Kwakman PHS, Kamp N, El Ghalbzouri A, Lohner K, Zaat SAJ, Drijfhout JW, Nibbering PH. de Breij A, et al. Among authors: drijfhout jw. Sci Transl Med. 2018 Jan 10;10(423):eaan4044. doi: 10.1126/scitranslmed.aan4044. Sci Transl Med. 2018. PMID: 29321257
Native thrombocidin-1 and unfolded thrombocidin-1 exert antimicrobial activity via distinct structural elements.
Kwakman PH, Krijgsveld J, de Boer L, Nguyen LT, Boszhard L, Vreede J, Dekker HL, Speijer D, Drijfhout JW, te Velde AA, Crielaard W, Vogel HJ, Vandenbroucke-Grauls CM, Zaat SA. Kwakman PH, et al. Among authors: drijfhout jw. J Biol Chem. 2011 Dec 16;286(50):43506-14. doi: 10.1074/jbc.M111.248641. Epub 2011 Oct 24. J Biol Chem. 2011. PMID: 22025617 Free PMC article.
Development of a nose cream containing the synthetic antimicrobial peptide P60.4Ac for eradication of methicillin-resistant Staphylococcus aureus carriage.
Göblyös A, Schimmel KJ, Valentijn AR, Fathers LM, Cordfunke RA, Chan HL, Oostendorp J, Nibbering PH, Drijfhout JW, Hiemstra PS, Hartigh JD. Göblyös A, et al. Among authors: drijfhout jw. J Pharm Sci. 2013 Oct;102(10):3539-44. doi: 10.1002/jps.23695. Epub 2013 Aug 17. J Pharm Sci. 2013. PMID: 23955373
A novel secreted metalloprotease (CD2830) from Clostridium difficile cleaves specific proline sequences in LPXTG cell surface proteins.
Hensbergen PJ, Klychnikov OI, Bakker D, van Winden VJ, Ras N, Kemp AC, Cordfunke RA, Dragan I, Deelder AM, Kuijper EJ, Corver J, Drijfhout JW, van Leeuwen HC. Hensbergen PJ, et al. Among authors: drijfhout jw. Mol Cell Proteomics. 2014 May;13(5):1231-44. doi: 10.1074/mcp.M113.034728. Epub 2014 Mar 12. Mol Cell Proteomics. 2014. PMID: 24623589 Free PMC article.
Phospholipid-driven differences determine the action of the synthetic antimicrobial peptide OP-145 on Gram-positive bacterial and mammalian membrane model systems.
Malanovic N, Leber R, Schmuck M, Kriechbaum M, Cordfunke RA, Drijfhout JW, de Breij A, Nibbering PH, Kolb D, Lohner K. Malanovic N, et al. Among authors: drijfhout jw. Biochim Biophys Acta. 2015 Oct;1848(10 Pt A):2437-47. doi: 10.1016/j.bbamem.2015.07.010. Epub 2015 Jul 23. Biochim Biophys Acta. 2015. PMID: 26210299 Free article.
301 results