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Blockade of Tim-3 binding to phosphatidylserine and CEACAM1 is a shared feature of anti-Tim-3 antibodies that have functional efficacy.
Sabatos-Peyton CA, Nevin J, Brock A, Venable JD, Tan DJ, Kassam N, Xu F, Taraszka J, Wesemann L, Pertel T, Acharya N, Klapholz M, Etminan Y, Jiang X, Huang YH, Blumberg RS, Kuchroo VK, Anderson AC. Sabatos-Peyton CA, et al. Among authors: kassam n. Oncoimmunology. 2017 Nov 9;7(2):e1385690. doi: 10.1080/2162402X.2017.1385690. eCollection 2018. Oncoimmunology. 2017. PMID: 29308307 Free PMC article.
TIM-4 expressed on APCs induces T cell expansion and survival.
Rodriguez-Manzanet R, Meyers JH, Balasubramanian S, Slavik J, Kassam N, Dardalhon V, Greenfield EA, Anderson AC, Sobel RA, Hafler DA, Strom TB, Kuchroo VK. Rodriguez-Manzanet R, et al. Among authors: kassam n. J Immunol. 2008 Apr 1;180(7):4706-13. doi: 10.4049/jimmunol.180.7.4706. J Immunol. 2008. PMID: 18354194 Free PMC article.
Cutting edge: TIGIT has T cell-intrinsic inhibitory functions.
Joller N, Hafler JP, Brynedal B, Kassam N, Spoerl S, Levin SD, Sharpe AH, Kuchroo VK. Joller N, et al. Among authors: kassam n. J Immunol. 2011 Feb 1;186(3):1338-42. doi: 10.4049/jimmunol.1003081. Epub 2011 Jan 3. J Immunol. 2011. PMID: 21199897 Free PMC article.
Negative immune regulator Tim-3 is overexpressed on T cells in hepatitis C virus infection and its blockade rescues dysfunctional CD4+ and CD8+ T cells.
Golden-Mason L, Palmer BE, Kassam N, Townshend-Bulson L, Livingston S, McMahon BJ, Castelblanco N, Kuchroo V, Gretch DR, Rosen HR. Golden-Mason L, et al. Among authors: kassam n. J Virol. 2009 Sep;83(18):9122-30. doi: 10.1128/JVI.00639-09. Epub 2009 Jul 8. J Virol. 2009. PMID: 19587053 Free PMC article.
82 results