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Use of the complement inhibitor Coversin to treat HSCT-associated TMA.
Goodship THJ, Pinto F, Weston-Davies WH, Silva J, Nishimura JI, Nunn MA, Mackie I, Machin SJ, Palm L, Pryce JW, Chiesa R, Amrolia P, Veys P. Goodship THJ, et al. Among authors: nunn ma. Blood Adv. 2017 Jul 3;1(16):1254-1258. doi: 10.1182/bloodadvances.2016002832. eCollection 2017 Jul 11. Blood Adv. 2017. PMID: 29296765 Free PMC article.
Structural basis for therapeutic inhibition of complement C5.
Jore MM, Johnson S, Sheppard D, Barber NM, Li YI, Nunn MA, Elmlund H, Lea SM. Jore MM, et al. Among authors: nunn ma. Nat Struct Mol Biol. 2016 May;23(5):378-86. doi: 10.1038/nsmb.3196. Epub 2016 Mar 28. Nat Struct Mol Biol. 2016. PMID: 27018802 Free PMC article.
Complement factor 5 blockade reduces porcine myocardial infarction size and improves immediate cardiac function.
Pischke SE, Gustavsen A, Orrem HL, Egge KH, Courivaud F, Fontenelle H, Despont A, Bongoni AK, Rieben R, Tønnessen TI, Nunn MA, Scott H, Skulstad H, Barratt-Due A, Mollnes TE. Pischke SE, et al. Among authors: nunn ma. Basic Res Cardiol. 2017 May;112(3):20. doi: 10.1007/s00395-017-0610-9. Epub 2017 Mar 3. Basic Res Cardiol. 2017. PMID: 28258298 Free PMC article.
Combined inhibition of C5 and CD14 efficiently attenuated the inflammatory response in a porcine model of meningococcal sepsis.
Hellerud BC, Orrem HL, Dybwik K, Pischke SE, Baratt-Due A, Castellheim A, Fure H, Bergseth G, Christiansen D, Nunn MA, Espevik T, Lau C, Brandtzæg P, Nielsen EW, Mollnes TE. Hellerud BC, et al. Among authors: nunn ma. J Intensive Care. 2017 Feb 27;5:21. doi: 10.1186/s40560-017-0217-0. eCollection 2017. J Intensive Care. 2017. PMID: 28261486 Free PMC article.
43 results