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Mapping genetic variations to three-dimensional protein structures to enhance variant interpretation: a proposed framework.
Glusman G, Rose PW, Prlić A, Dougherty J, Duarte JM, Hoffman AS, Barton GJ, Bendixen E, Bergquist T, Bock C, Brunk E, Buljan M, Burley SK, Cai B, Carter H, Gao J, Godzik A, Heuer M, Hicks M, Hrabe T, Karchin R, Leman JK, Lane L, Masica DL, Mooney SD, Moult J, Omenn GS, Pearl F, Pejaver V, Reynolds SM, Rokem A, Schwede T, Song S, Tilgner H, Valasatava Y, Zhang Y, Deutsch EW. Glusman G, et al. Among authors: brunk e. Genome Med. 2017 Dec 18;9(1):113. doi: 10.1186/s13073-017-0509-y. Genome Med. 2017. PMID: 29254494 Free PMC article. Review.
Recon3D enables a three-dimensional view of gene variation in human metabolism.
Brunk E, Sahoo S, Zielinski DC, Altunkaya A, Dräger A, Mih N, Gatto F, Nilsson A, Preciat Gonzalez GA, Aurich MK, Prlić A, Sastry A, Danielsdottir AD, Heinken A, Noronha A, Rose PW, Burley SK, Fleming RMT, Nielsen J, Thiele I, Palsson BO. Brunk E, et al. Nat Biotechnol. 2018 Mar;36(3):272-281. doi: 10.1038/nbt.4072. Epub 2018 Feb 19. Nat Biotechnol. 2018. PMID: 29457794 Free PMC article.
ssbio: a Python framework for structural systems biology.
Mih N, Brunk E, Chen K, Catoiu E, Sastry A, Kavvas E, Monk JM, Zhang Z, Palsson BO. Mih N, et al. Among authors: brunk e. Bioinformatics. 2018 Jun 15;34(12):2155-2157. doi: 10.1093/bioinformatics/bty077. Bioinformatics. 2018. PMID: 29444205 Free PMC article.
Systems biology of the structural proteome.
Brunk E, Mih N, Monk J, Zhang Z, O'Brien EJ, Bliven SE, Chen K, Chang RL, Bourne PE, Palsson BO. Brunk E, et al. BMC Syst Biol. 2016 Mar 11;10:26. doi: 10.1186/s12918-016-0271-6. BMC Syst Biol. 2016. PMID: 26969117 Free PMC article.
Model-driven discovery of underground metabolic functions in Escherichia coli.
Guzmán GI, Utrilla J, Nurk S, Brunk E, Monk JM, Ebrahim A, Palsson BO, Feist AM. Guzmán GI, et al. Among authors: brunk e. Proc Natl Acad Sci U S A. 2015 Jan 20;112(3):929-34. doi: 10.1073/pnas.1414218112. Epub 2015 Jan 6. Proc Natl Acad Sci U S A. 2015. PMID: 25564669 Free PMC article.
47 results