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High HCV subtype heterogeneity in a chronically infected general population revealed by high-resolution hepatitis C virus subtyping.
Rodriguez-Frias F, Nieto-Aponte L, Gregori J, Garcia-Cehic D, Casillas R, Tabernero D, Homs M, Blasi M, Vila M, Chen Q, Vargas V, Castells L, Viladomiu L, Genesca J, Minguez B, Augustin S, Riveiro-Barciela M, Carbonell J, Perales C, Soria ME, Asensio M, Llorens M, Ordeig L, Godoy C, Buti M, Esteban R, Pumarola T, Esteban JI, Quer J. Rodriguez-Frias F, et al. Among authors: chen q. Clin Microbiol Infect. 2017 Oct;23(10):775.e1-775.e6. doi: 10.1016/j.cmi.2017.02.007. Epub 2017 Feb 10. Clin Microbiol Infect. 2017. PMID: 28192235 Free article.
New real-time-PCR method to identify single point mutations in hepatitis C virus.
Chen Q, Belmonte I, Buti M, Nieto L, Garcia-Cehic D, Gregori J, Perales C, Ordeig L, Llorens M, Soria ME, Esteban R, Esteban JI, Rodriguez-Frias F, Quer J. Chen Q, et al. World J Gastroenterol. 2016 Nov 21;22(43):9604-9612. doi: 10.3748/wjg.v22.i43.9604. World J Gastroenterol. 2016. PMID: 27920481 Free PMC article.
Assessment of a Novel Automatic Real-Time PCR Assay on the Cobas 4800 Analyzer as a Screening Platform for Hepatitis C Virus Genotyping in Clinical Practice: Comparison with Massive Sequencing.
Nieto-Aponte L, Quer J, Ruiz-Ripa A, Tabernero D, Gonzalez C, Gregori J, Vila M, Asensio M, Garcia-Cehic D, Ruiz G, Chen Q, Ordeig L, Llorens M, Saez M, Esteban JI, Esteban R, Buti M, Pumarola T, Rodriguez-Frias F. Nieto-Aponte L, et al. Among authors: chen q. J Clin Microbiol. 2017 Feb;55(2):504-509. doi: 10.1128/JCM.01960-16. Epub 2016 Dec 7. J Clin Microbiol. 2017. PMID: 27927921 Free PMC article.
Broad and Dynamic Diversification of Infectious Hepatitis C Virus in a Cell Culture Environment.
Gallego I, Soria ME, García-Crespo C, Chen Q, Martínez-Barragán P, Khalfaoui S, Martínez-González B, Sanchez-Martin I, Palacios-Blanco I, de Ávila AI, García-Cehic D, Esteban JI, Gómez J, Briones C, Gregori J, Quer J, Perales C, Domingo E. Gallego I, et al. Among authors: chen q. J Virol. 2020 Feb 28;94(6):e01856-19. doi: 10.1128/JVI.01856-19. Print 2020 Feb 28. J Virol. 2020. PMID: 31852791 Free PMC article.
Deep-sequencing reveals broad subtype-specific HCV resistance mutations associated with treatment failure.
Chen Q, Perales C, Soria ME, García-Cehic D, Gregori J, Rodríguez-Frías F, Buti M, Crespo J, Calleja JL, Tabernero D, Vila M, Lázaro F, Rando-Segura A, Nieto-Aponte L, Llorens-Revull M, Cortese MF, Fernandez-Alonso I, Castellote J, Niubó J, Imaz A, Xiol X, Castells L, Riveiro-Barciela M, Llaneras J, Navarro J, Vargas-Blasco V, Augustin S, Conde I, Rubín Á, Prieto M, Torras X, Margall N, Forns X, Mariño Z, Lens S, Bonacci M, Pérez-Del-Pulgar S, Londoño MC, García-Buey ML, Sanz-Cameno P, Morillas R, Martró E, Saludes V, Masnou-Ridaura H, Salmerón J, Quíles R, Carrión JA, Forné M, Rosinach M, Fernández I, García-Samaniego J, Madejón A, Castillo-Grau P, López-Núñez C, Ferri MJ, Durández R, Sáez-Royuela F, Diago M, Gimeno C, Medina R, Buenestado J, Bernet A, Turnes J, Trigo-Daporta M, Hernández-Guerra M, Delgado-Blanco M, Cañizares A, Arenas JI, Gomez-Alonso MJ, Rodríguez M, Deig E, Olivé G, Río OD, Cabezas J, Quiñones I, Roget M, Montoliu S, García-Costa J, Force L, Blanch S, Miralbés M, López-de-Goicoechea MJ, García-Flores A, Saumoy M, Casanovas T, Baliellas C, Gilabert P, Martin-Cardona A, Roca R, Barenys M, Villaverde J, Salord S, Camps B, Silvan di Yacovo M, Ocaña I, Saule… See abstract for full author list ➔ Chen Q, et al. Antiviral Res. 2020 Feb;174:104694. doi: 10.1016/j.antiviral.2019.104694. Epub 2019 Dec 16. Antiviral Res. 2020. PMID: 31857134 Free article.
Amino Acid Substitutions Associated with Treatment Failure for Hepatitis C Virus Infection.
Soria ME, García-Crespo C, Martínez-González B, Vázquez-Sirvent L, Lobo-Vega R, de Ávila AI, Gallego I, Chen Q, García-Cehic D, Llorens-Revull M, Briones C, Gómez J, Ferrer-Orta C, Verdaguer N, Gregori J, Rodríguez-Frías F, Buti M, Esteban JI, Domingo E, Quer J, Perales C. Soria ME, et al. Among authors: chen q. J Clin Microbiol. 2020 Nov 18;58(12):e01985-20. doi: 10.1128/JCM.01985-20. Print 2020 Nov 18. J Clin Microbiol. 2020. PMID: 32999010 Free PMC article.
Baseline hepatitis C virus resistance-associated substitutions present at frequencies lower than 15% may be clinically significant.
Perales C, Chen Q, Soria ME, Gregori J, Garcia-Cehic D, Nieto-Aponte L, Castells L, Imaz A, Llorens-Revull M, Domingo E, Buti M, Esteban JI, Rodriguez-Frias F, Quer J. Perales C, et al. Among authors: chen q. Infect Drug Resist. 2018 Nov 8;11:2207-2210. doi: 10.2147/IDR.S172226. eCollection 2018. Infect Drug Resist. 2018. PMID: 30519058 Free PMC article.
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