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Melanoma Therapeutic Strategies that Select against Resistance by Exploiting MYC-Driven Evolutionary Convergence.
Cell Rep. 2017 Dec 5;21(10):2796-2812. doi: 10.1016/j.celrep.2017.11.022.
Cell Rep. 2017.
PMID: 29212027
Free PMC article.
MAPK Pathway Suppression Unmasks Latent DNA Repair Defects and Confers a Chemical Synthetic Vulnerability in BRAF-, NRAS-, and NF1-Mutant Melanomas.
Maertens O, Kuzmickas R, Manchester HE, Emerson CE, Gavin AG, Guild CJ, Wong TC, De Raedt T, Bowman-Colin C, Hatchi E, Garraway LA, Flaherty KT, Pathania S, Elledge SJ, Cichowski K.
Maertens O, et al. Among authors: manchester he.
Cancer Discov. 2019 Apr;9(4):526-545. doi: 10.1158/2159-8290.CD-18-0879. Epub 2019 Feb 1.
Cancer Discov. 2019.
PMID: 30709805
Free PMC article.
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ARID1B is a specific vulnerability in ARID1A-mutant cancers.
Helming KC, Wang X, Wilson BG, Vazquez F, Haswell JR, Manchester HE, Kim Y, Kryukov GV, Ghandi M, Aguirre AJ, Jagani Z, Wang Z, Garraway LA, Hahn WC, Roberts CW.
Helming KC, et al. Among authors: manchester he.
Nat Med. 2014 Mar;20(3):251-4. doi: 10.1038/nm.3480. Epub 2014 Feb 23.
Nat Med. 2014.
PMID: 24562383
Free PMC article.
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The SWI/SNF chromatin remodelling complex is required for maintenance of lineage specific enhancers.
Alver BH, Kim KH, Lu P, Wang X, Manchester HE, Wang W, Haswell JR, Park PJ, Roberts CW.
Alver BH, et al. Among authors: manchester he.
Nat Commun. 2017 Mar 6;8:14648. doi: 10.1038/ncomms14648.
Nat Commun. 2017.
PMID: 28262751
Free PMC article.
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Targeting Cholesterol Biosynthesis with Statins Synergizes with AKT Inhibitors in Triple-Negative Breast Cancer.
Hillis AL, Martin TD, Manchester HE, Högström J, Zhang N, Lecky E, Kozlova N, Lee J, Persky NS, Root DE, Brown M, Cichowski K, Elledge SJ, Muranen T, Fruman DA, Barry ST, Clohessy JG, Madsen RR, Toker A.
Hillis AL, et al. Among authors: manchester he.
Cancer Res. 2024 Jul 18. doi: 10.1158/0008-5472.CAN-24-0970. Online ahead of print.
Cancer Res. 2024.
PMID: 39024548
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