O'Leary C - Search Results

1

Macrophage enzyme and reduced inflammation drive brain correction of mucopolysaccharidosis IIIB by stem cell gene therapy.

Holley RJ, Ellison SM, Fil D, O'Leary C, McDermott J, Senthivel N, Langford-Smith AWW, Wilkinson FL, D'Souza Z, Parker H, Liao A, Rowlston S, Gleitz HFE, Kan SH, Dickson PI, Bigger BW. Holley RJ, et al. Brain. 2018 Jan 1;141(1):99-116. doi: 10.1093/brain/awx311. Brain. 2018. PMID: 29186350

2

Identification of age-dependent motor and neuropsychological behavioural abnormalities in a mouse model of Mucopolysaccharidosis Type II.

Gleitz HF, O'Leary C, Holley RJ, Bigger BW. Gleitz HF, et al. PLoS One. 2017 Feb 16;12(2):e0172435. doi: 10.1371/journal.pone.0172435. eCollection 2017. PLoS One. 2017. PMID: 28207863 Free PMC article.

3

A nonmyeloablative chimeric mouse model accurately defines microglia and macrophage contribution in glioma.

Yu K, Youshani AS, Wilkinson FL, O'Leary C, Cook P, Laaniste L, Liao A, Mosses D, Waugh C, Shorrock H, Pathmanaban O, Macdonald A, Kamaly-Asl I, Roncaroli F, Bigger BW. Yu K, et al. Neuropathol Appl Neurobiol. 2019 Feb;45(2):119-140. doi: 10.1111/nan.12489. Epub 2018 May 17. Neuropathol Appl Neurobiol. 2019. PMID: 29679380 Free PMC article.

4

A novel adeno-associated virus capsid with enhanced neurotropism corrects a lysosomal transmembrane enzyme deficiency.

Tordo J, O'Leary C, Antunes ASLM, Palomar N, Aldrin-Kirk P, Basche M, Bennett A, D'Souza Z, Gleitz H, Godwin A, Holley RJ, Parker H, Liao AY, Rouse P, Youshani AS, Dridi L, Martins C, Levade T, Stacey KB, Davis DM, Dyer A, Clément N, Björklund T, Ali RR, Agbandje-McKenna M, Rahim AA, Pshezhetsky A, Waddington SN, Linden RM, Bigger BW, Henckaerts E. Tordo J, et al. Brain. 2018 Jul 1;141(7):2014-2031. doi: 10.1093/brain/awy126. Brain. 2018. PMID: 29788236 Free PMC article.

5

Brain-targeted stem cell gene therapy corrects mucopolysaccharidosis type II via multiple mechanisms.

Gleitz HF, Liao AY, Cook JR, Rowlston SF, Forte GM, D'Souza Z, O'Leary C, Holley RJ, Bigger BW. Gleitz HF, et al. EMBO Mol Med. 2018 Jul;10(7):e8730. doi: 10.15252/emmm.201708730. EMBO Mol Med. 2018. PMID: 29884617 Free PMC article.

6

Non-myeloablative busulfan chimeric mouse models are less pro-inflammatory than head-shielded irradiation for studying immune cell interactions in brain tumours.

Youshani AS, Rowlston S, O'Leary C, Forte G, Parker H, Liao A, Telfer B, Williams K, Kamaly-Asl ID, Bigger BW. Youshani AS, et al. J Neuroinflammation. 2019 Feb 5;16(1):25. doi: 10.1186/s12974-019-1410-y. J Neuroinflammation. 2019. PMID: 30722781 Free PMC article.

7

Strategies for the Induction of Immune Tolerance to Enzyme Replacement Therapy in Mucopolysaccharidosis Type I.

Ghosh A, Liao A, O'Leary C, Mercer J, Tylee K, Goenka A, Holley R, Jones SA, Bigger BW. Ghosh A, et al. Mol Ther Methods Clin Dev. 2019 Mar 2;13:321-333. doi: 10.1016/j.omtm.2019.02.007. eCollection 2019 Jun 14. Mol Ther Methods Clin Dev. 2019. PMID: 30976609 Free PMC article.

8

An Improved Adeno-Associated Virus Vector for Neurological Correction of the Mouse Model of Mucopolysaccharidosis IIIA.

Gray AL, O'Leary C, Liao A, Agúndez L, Youshani AS, Gleitz HF, Parker H, Taylor JT, Danos O, Hocquemiller M, Palomar N, Linden RM, Henckaerts E, Holley RJ, Bigger BW. Gray AL, et al. Hum Gene Ther. 2019 Sep;30(9):1052-1066. doi: 10.1089/hum.2018.189. Epub 2019 Jun 4. Hum Gene Ther. 2019. PMID: 31020862

9

Haematopoietic stem cell gene therapy with IL-1Ra rescues cognitive loss in mucopolysaccharidosis IIIA.

Parker H, Ellison SM, Holley RJ, O'Leary C, Liao A, Asadi J, Glover E, Ghosh A, Jones S, Wilkinson FL, Brough D, Pinteaux E, Boutin H, Bigger BW. Parker H, et al. EMBO Mol Med. 2020 Mar 6;12(3):e11185. doi: 10.15252/emmm.201911185. Epub 2020 Feb 14. EMBO Mol Med. 2020. PMID: 32057196 Free PMC article.

10

High dose genistein in Sanfilippo syndrome: A randomised controlled trial.

Ghosh A, Rust S, Langford-Smith K, Weisberg D, Canal M, Breen C, Hepburn M, Tylee K, Vaz FM, Vail A, Wijburg F, O'Leary C, Parker H, Wraith JE, Bigger BW, Jones SA. Ghosh A, et al. J Inherit Metab Dis. 2021 Sep;44(5):1248-1262. doi: 10.1002/jimd.12407. Epub 2021 Jun 13. J Inherit Metab Dis. 2021. PMID: 34047372 Clinical Trial.

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