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Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR-Cas9 genome-editing efficiency.
Nat Biotechnol. 2018 Jan;36(1):95-102. doi: 10.1038/nbt.4021. Epub 2017 Nov 27.
Nat Biotechnol. 2018.
PMID: 29176614
Free PMC article.
A substrate binding model for the KEOPS tRNA modifying complex.
Beenstock J, Ona SM, Porat J, Orlicky S, Wan LCK, Ceccarelli DF, Maisonneuve P, Szilard RK, Yin Z, Setiaputra D, Mao DYL, Khan M, Raval S, Schriemer DC, Bayfield MA, Durocher D, Sicheri F.
Beenstock J, et al. Among authors: wan lck.
Nat Commun. 2020 Dec 4;11(1):6233. doi: 10.1038/s41467-020-19990-5.
Nat Commun. 2020.
PMID: 33277478
Free PMC article.
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Proteomic analysis of the human KEOPS complex identifies C14ORF142 as a core subunit homologous to yeast Gon7.
Wan LC, Maisonneuve P, Szilard RK, Lambert JP, Ng TF, Manczyk N, Huang H, Laister R, Caudy AA, Gingras AC, Durocher D, Sicheri F.
Wan LC, et al.
Nucleic Acids Res. 2017 Jan 25;45(2):805-817. doi: 10.1093/nar/gkw1181. Epub 2016 Nov 29.
Nucleic Acids Res. 2017.
PMID: 27903914
Free PMC article.
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Structural and functional characterization of KEOPS dimerization by Pcc1 and its role in t6A biosynthesis.
Wan LC, Pillon MC, Thevakumaran N, Sun Y, Chakrabartty A, Guarné A, Kurinov I, Durocher D, Sicheri F.
Wan LC, et al.
Nucleic Acids Res. 2016 Aug 19;44(14):6971-80. doi: 10.1093/nar/gkw542. Epub 2016 Jun 14.
Nucleic Acids Res. 2016.
PMID: 27302132
Free PMC article.
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Reconstitution and characterization of eukaryotic N6-threonylcarbamoylation of tRNA using a minimal enzyme system.
Wan LC, Mao DY, Neculai D, Strecker J, Chiovitti D, Kurinov I, Poda G, Thevakumaran N, Yuan F, Szilard RK, Lissina E, Nislow C, Caudy AA, Durocher D, Sicheri F.
Wan LC, et al.
Nucleic Acids Res. 2013 Jul;41(12):6332-46. doi: 10.1093/nar/gkt322. Epub 2013 Apr 25.
Nucleic Acids Res. 2013.
PMID: 23620299
Free PMC article.
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Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine.
Mao DY, Neculai D, Downey M, Orlicky S, Haffani YZ, Ceccarelli DF, Ho JS, Szilard RK, Zhang W, Ho CS, Wan L, Fares C, Rumpel S, Kurinov I, Arrowsmith CH, Durocher D, Sicheri F.
Mao DY, et al.
Mol Cell. 2008 Oct 24;32(2):259-75. doi: 10.1016/j.molcel.2008.10.002.
Mol Cell. 2008.
PMID: 18951093
Free PMC article.
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Dimeric structure of pseudokinase RNase L bound to 2-5A reveals a basis for interferon-induced antiviral activity.
Huang H, Zeqiraj E, Dong B, Jha BK, Duffy NM, Orlicky S, Thevakumaran N, Talukdar M, Pillon MC, Ceccarelli DF, Wan LC, Juang YC, Mao DY, Gaughan C, Brinton MA, Perelygin AA, Kourinov I, Guarné A, Silverman RH, Sicheri F.
Huang H, et al.
Mol Cell. 2014 Jan 23;53(2):221-34. doi: 10.1016/j.molcel.2013.12.025.
Mol Cell. 2014.
PMID: 24462203
Free PMC article.
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Formin-mediated actin polymerization promotes Salmonella invasion.
Truong D, Brabant D, Bashkurov M, Wan LC, Braun V, Heo WD, Meyer T, Pelletier L, Copeland J, Brumell JH.
Truong D, et al.
Cell Microbiol. 2013 Dec;15(12):2051-63. doi: 10.1111/cmi.12173. Epub 2013 Aug 13.
Cell Microbiol. 2013.
PMID: 23869992
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