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Converting Insulin-like Growth Factors 1 and 2 into High-Affinity Ligands for Insulin Receptor Isoform A by the Introduction of an Evolutionarily Divergent Mutation.
Macháčková K, Chrudinová M, Radosavljević J, Potalitsyn P, Křížková K, Fábry M, Selicharová I, Collinsová M, Brzozowski AM, Žáková L, Jiráček J. Macháčková K, et al. Biochemistry. 2018 Apr 24;57(16):2373-2382. doi: 10.1021/acs.biochem.7b01260. Epub 2018 Apr 10. Biochemistry. 2018. PMID: 29608283 Free article.
A versatile insulin analog with high potency for both insulin and insulin-like growth factor 1 receptors: Structural implications for receptor binding.
Chrudinová M, Žáková L, Marek A, Socha O, Buděšínský M, Hubálek M, Pícha J, Macháčková K, Jiráček J, Selicharová I. Chrudinová M, et al. Among authors: machackova k. J Biol Chem. 2018 Oct 26;293(43):16818-16829. doi: 10.1074/jbc.RA118.004852. Epub 2018 Sep 13. J Biol Chem. 2018. PMID: 30213860 Free PMC article.
Mutations at hypothetical binding site 2 in insulin and insulin-like growth factors 1 and 2 result in receptor- and hormone-specific responses.
Macháčková K, Mlčochová K, Potalitsyn P, Hanková K, Socha O, Buděšínský M, Muždalo A, Lepšík M, Černeková M, Radosavljević J, Fábry M, Mitrová K, Chrudinová M, Lin J, Yurenko Y, Hobza P, Selicharová I, Žáková L, Jiráček J. Macháčková K, et al. J Biol Chem. 2019 Nov 15;294(46):17371-17382. doi: 10.1074/jbc.RA119.010072. Epub 2019 Sep 26. J Biol Chem. 2019. PMID: 31558604 Free PMC article.
11 results