Parker EJ - Search Results

1

Datasets, processing and refinement details for Mtb-AnPRT: inhibitor structures with various space groups.

Evans GL, Furkert DP, Abermil N, Kundu P, de Lange KM, Parker EJ, Brimble MA, Baker EN, Lott JS. Evans GL, et al. Among authors: parker ej. Data Brief. 2017 Oct 31;15:1019-1029. doi: 10.1016/j.dib.2017.10.051. eCollection 2017 Dec. Data Brief. 2017. PMID: 29167811 Free PMC article.

2

The structure of 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis reveals a common catalytic scaffold and ancestry for type I and type II enzymes.

Webby CJ, Baker HM, Lott JS, Baker EN, Parker EJ. Webby CJ, et al. Among authors: parker ej. J Mol Biol. 2005 Dec 9;354(4):927-39. doi: 10.1016/j.jmb.2005.09.093. Epub 2005 Oct 21. J Mol Biol. 2005. PMID: 16288916

3

Crystallization and preliminary X-ray crystallographic analysis of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Mycobacterium tuberculosis.

Webby CJ, Lott JS, Baker HM, Baker EN, Parker EJ. Webby CJ, et al. Among authors: parker ej. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Apr 1;61(Pt 4):403-6. doi: 10.1107/S1744309105007931. Epub 2005 Mar 24. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005. PMID: 16511053 Free PMC article.

4

Synergistic allostery, a sophisticated regulatory network for the control of aromatic amino acid biosynthesis in Mycobacterium tuberculosis.

Webby CJ, Jiao W, Hutton RD, Blackmore NJ, Baker HM, Baker EN, Jameson GB, Parker EJ. Webby CJ, et al. Among authors: parker ej. J Biol Chem. 2010 Oct 1;285(40):30567-76. doi: 10.1074/jbc.M110.111856. Epub 2010 Jul 27. J Biol Chem. 2010. PMID: 20667835 Free PMC article.

5

Potent inhibitors of a shikimate pathway enzyme from Mycobacterium tuberculosis: combining mechanism- and modeling-based design.

Reichau S, Jiao W, Walker SR, Hutton RD, Baker EN, Parker EJ. Reichau S, et al. Among authors: parker ej. J Biol Chem. 2011 May 6;286(18):16197-207. doi: 10.1074/jbc.M110.211649. Epub 2011 Mar 15. J Biol Chem. 2011. PMID: 21454647 Free PMC article.

6

Removal of the C-terminal regulatory domain of α-isopropylmalate synthase disrupts functional substrate binding.

Huisman FH, Koon N, Bulloch EM, Baker HM, Baker EN, Squire CJ, Parker EJ. Huisman FH, et al. Among authors: parker ej. Biochemistry. 2012 Mar 20;51(11):2289-97. doi: 10.1021/bi201717j. Epub 2012 Mar 6. Biochemistry. 2012. PMID: 22352945

7

Three sites and you are out: ternary synergistic allostery controls aromatic amino acid biosynthesis in Mycobacterium tuberculosis.

Blackmore NJ, Reichau S, Jiao W, Hutton RD, Baker EN, Jameson GB, Parker EJ. Blackmore NJ, et al. Among authors: parker ej. J Mol Biol. 2013 May 13;425(9):1582-92. doi: 10.1016/j.jmb.2012.12.019. Epub 2012 Dec 28. J Mol Biol. 2013. PMID: 23274137

8

The substrate capture mechanism of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase provides a mode for inhibition.

Castell A, Short FL, Evans GL, Cookson TV, Bulloch EM, Joseph DD, Lee CE, Parker EJ, Baker EN, Lott JS. Castell A, et al. Among authors: parker ej. Biochemistry. 2013 Mar 12;52(10):1776-87. doi: 10.1021/bi301387m. Epub 2013 Feb 28. Biochemistry. 2013. PMID: 23363292

9

Alternative substrates reveal catalytic cycle and key binding events in the reaction catalysed by anthranilate phosphoribosyltransferase from Mycobacterium tuberculosis.

Cookson TV, Castell A, Bulloch EM, Evans GL, Short FL, Baker EN, Lott JS, Parker EJ. Cookson TV, et al. Among authors: parker ej. Biochem J. 2014 Jul 1;461(1):87-98. doi: 10.1042/BJ20140209. Biochem J. 2014. PMID: 24712732

10

Complex Formation between Two Biosynthetic Enzymes Modifies the Allosteric Regulatory Properties of Both: AN EXAMPLE OF MOLECULAR SYMBIOSIS.

Blackmore NJ, Nazmi AR, Hutton RD, Webby MN, Baker EN, Jameson GB, Parker EJ. Blackmore NJ, et al. Among authors: parker ej. J Biol Chem. 2015 Jul 17;290(29):18187-18198. doi: 10.1074/jbc.M115.638700. Epub 2015 Jun 1. J Biol Chem. 2015. PMID: 26032422 Free PMC article.

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