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Patient-specific molecular alterations are associated with metastatic clear cell renal cell cancer progressing under tyrosine kinase inhibitor therapy.
Dietz S, Sültmann H, Du Y, Reisinger E, Riediger AL, Volckmar AL, Stenzinger A, Schlesner M, Jäger D, Hohenfellner M, Duensing S, Grüllich C, Pahernik S. Dietz S, et al. Among authors: pahernik s. Oncotarget. 2017 May 23;8(43):74049-74057. doi: 10.18632/oncotarget.18200. eCollection 2017 Sep 26. Oncotarget. 2017. PMID: 29088767 Free PMC article.
Phenotypic drug screening and target validation for improved personalized therapy reveal the complexity of phenotype-genotype correlations in clear cell renal cell carcinoma.
Schneider M, Schüler J, Höfflin R, Korzeniewski N, Grüllich C, Roth W, Teber D, Hadaschik B, Pahernik S, Hohenfellner M, Duensing S. Schneider M, et al. Among authors: pahernik s. Urol Oncol. 2014 Aug;32(6):877-84. doi: 10.1016/j.urolonc.2014.03.011. Epub 2014 Jun 11. Urol Oncol. 2014. PMID: 24929890
Efficacy of targeted treatment beyond third-line therapy in metastatic kidney cancer: retrospective analysis from a large-volume cancer center.
Vallet S, Pahernik S, Höfner T, Tosev G, Hadaschik B, Duensing S, Sedlaczek O, Hohenfellner M, Jäger D, Grüllich C; Renal Cancer Center at the National Center for Tumor Diseases (NCT) Heidelberg, Germany. Vallet S, et al. Among authors: pahernik s. Clin Genitourin Cancer. 2015 Jun;13(3):e145-52. doi: 10.1016/j.clgc.2014.12.012. Epub 2014 Dec 30. Clin Genitourin Cancer. 2015. PMID: 25596830
Spatial niche formation but not malignant progression is a driving force for intratumoural heterogeneity.
Hoefflin R, Lahrmann B, Warsow G, Hübschmann D, Spath C, Walter B, Chen X, Hofer L, Macher-Goeppinger S, Tolstov Y, Korzeniewski N, Duensing A, Grüllich C, Jäger D, Perner S, Schönberg G, Nyarangi-Dix J, Isaac S, Hatiboglu G, Teber D, Hadaschik B, Pahernik S, Roth W, Eils R, Schlesner M, Sültmann H, Hohenfellner M, Grabe N, Duensing S. Hoefflin R, et al. Among authors: pahernik s. Nat Commun. 2016 Jun 13;7:ncomms11845. doi: 10.1038/ncomms11845. Nat Commun. 2016. PMID: 27291893 Free PMC article.
209 results