Zhang Y - Search Results

1

Discovery of novel BET inhibitors by drug repurposing of nitroxoline and its analogues.

Jiang H, Xing J, Wang C, Zhang H, Yue L, Wan X, Chen W, Ding H, Xie Y, Tao H, Chen Z, Jiang H, Chen K, Chen S, Zheng M, Zhang Y, Luo C. Jiang H, et al. Among authors: zhang h, zhang y. Org Biomol Chem. 2017 Nov 15;15(44):9352-9361. doi: 10.1039/c7ob02369c. Org Biomol Chem. 2017. PMID: 29087414

2

Identification of Novel Disruptor of Telomeric Silencing 1-like (DOT1L) Inhibitors through Structure-Based Virtual Screening and Biological Assays.

Chen S, Li L, Chen Y, Hu J, Liu J, Liu YC, Liu R, Zhang Y, Meng F, Zhu K, Lu J, Zheng M, Chen K, Zhang J, Jiang H, Yao Z, Luo C. Chen S, et al. Among authors: zhang j, zhang y. J Chem Inf Model. 2016 Mar 28;56(3):527-34. doi: 10.1021/acs.jcim.5b00738. Epub 2016 Mar 4. J Chem Inf Model. 2016. PMID: 26914852

3

Identification of novel EZH2 inhibitors through pharmacophore-based virtual screening and biological assays.

Wu Y, Hu J, Ding H, Chen L, Zhang Y, Liu R, Xu P, Du D, Lu W, Liu J, Liu Y, Liu YC, Lu J, Zhang J, Yao Z, Luo C. Wu Y, et al. Among authors: zhang j, zhang y. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3813-7. doi: 10.1016/j.bmcl.2016.05.018. Epub 2016 May 30. Bioorg Med Chem Lett. 2016. PMID: 27289323

4

Identification of novel small-molecule inhibitors targeting menin-MLL interaction, repurposing the antidiarrheal loperamide.

Yue L, Du J, Ye F, Chen Z, Li L, Lian F, Zhang B, Zhang Y, Jiang H, Chen K, Li Y, Zhou B, Zhang N, Yang Y, Luo C. Yue L, et al. Among authors: zhang n, zhang b, zhang y. Org Biomol Chem. 2016 Sep 28;14(36):8503-19. doi: 10.1039/c6ob01248e. Epub 2016 Aug 19. Org Biomol Chem. 2016. PMID: 27541268

5

Discovery of novel BRD4 inhibitors by high-throughput screening, crystallography, and cell-based assays.

Sun Z, Zhang H, Chen Z, Xie Y, Jiang H, Chen L, Ding H, Zhang Y, Jiang H, Zheng M, Luo C. Sun Z, et al. Among authors: zhang h, zhang y. Bioorg Med Chem Lett. 2017 May 1;27(9):2003-2009. doi: 10.1016/j.bmcl.2017.03.012. Epub 2017 Mar 9. Bioorg Med Chem Lett. 2017. PMID: 28347667

6

Potent, Selective, and Cell Active Protein Arginine Methyltransferase 5 (PRMT5) Inhibitor Developed by Structure-Based Virtual Screening and Hit Optimization.

Mao R, Shao J, Zhu K, Zhang Y, Ding H, Zhang C, Shi Z, Jiang H, Sun D, Duan W, Luo C. Mao R, et al. Among authors: zhang c, zhang y. J Med Chem. 2017 Jul 27;60(14):6289-6304. doi: 10.1021/acs.jmedchem.7b00587. Epub 2017 Jul 12. J Med Chem. 2017. PMID: 28650658

7

Development of Potent Type I Protein Arginine Methyltransferase (PRMT) Inhibitors of Leukemia Cell Proliferation.

Wang C, Jiang H, Jin J, Xie Y, Chen Z, Zhang H, Lian F, Liu YC, Zhang C, Ding H, Chen S, Zhang N, Zhang Y, Jiang H, Chen K, Ye F, Yao Z, Luo C. Wang C, et al. Among authors: zhang n, zhang c, zhang h, zhang y. J Med Chem. 2017 Nov 9;60(21):8888-8905. doi: 10.1021/acs.jmedchem.7b01134. Epub 2017 Oct 27. J Med Chem. 2017. PMID: 29019697

8

Discovery of potent DOT1L inhibitors by AlphaLISA based High Throughput Screening assay.

Song Y, Li L, Chen Y, Liu J, Xiao S, Lian F, Zhang N, Ding H, Zhang Y, Chen K, Jiang H, Zhang C, Liu YC, Chen S, Luo C. Song Y, et al. Among authors: zhang n, zhang c, zhang y. Bioorg Med Chem. 2018 May 1;26(8):1751-1758. doi: 10.1016/j.bmc.2018.02.020. Epub 2018 Feb 24. Bioorg Med Chem. 2018. PMID: 29534934

9

Identification of small molecule inhibitors targeting the SMARCA2 bromodomain from a high-throughput screening assay.

Lu T, Hu JC, Lu WC, Han J, Ding H, Jiang H, Zhang YY, Yue LY, Chen SJ, Jiang HL, Chen KX, Chai HF, Luo C. Lu T, et al. Acta Pharmacol Sin. 2018 Sep;39(9):1544-1552. doi: 10.1038/aps.2017.188. Epub 2018 May 24. Acta Pharmacol Sin. 2018. PMID: 29795359 Free PMC article.

10

Discovery of novel trimethoxy-ring BRD4 bromodomain inhibitors: AlphaScreen assay, crystallography and cell-based assay.

Chen Z, Zhang H, Liu S, Xie Y, Jiang H, Lu W, Xu H, Yue L, Zhang Y, Ding H, Zheng M, Yu K, Chen K, Jiang H, Luo C. Chen Z, et al. Among authors: zhang h, zhang y. Medchemcomm. 2017 Mar 17;8(6):1322-1331. doi: 10.1039/c7md00083a. eCollection 2017 Jun 1. Medchemcomm. 2017. PMID: 30108844 Free PMC article.

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