Chen Z - Search Results

1

Discovery of novel BET inhibitors by drug repurposing of nitroxoline and its analogues.

Jiang H, Xing J, Wang C, Zhang H, Yue L, Wan X, Chen W, Ding H, Xie Y, Tao H, Chen Z, Jiang H, Chen K, Chen S, Zheng M, Zhang Y, Luo C. Jiang H, et al. Among authors: chen z, chen k, chen s, chen w. Org Biomol Chem. 2017 Nov 15;15(44):9352-9361. doi: 10.1039/c7ob02369c. Org Biomol Chem. 2017. PMID: 29087414

2

Discovery of Novel Inhibitors Targeting the Menin-Mixed Lineage Leukemia Interface Using Pharmacophore- and Docking-Based Virtual Screening.

Xu Y, Yue L, Wang Y, Xing J, Chen Z, Shi Z, Liu R, Liu YC, Luo X, Jiang H, Chen K, Luo C, Zheng M. Xu Y, et al. Among authors: chen z, chen k. J Chem Inf Model. 2016 Sep 26;56(9):1847-55. doi: 10.1021/acs.jcim.6b00185. Epub 2016 Aug 24. J Chem Inf Model. 2016. PMID: 27513308

3

Identification of novel small-molecule inhibitors targeting menin-MLL interaction, repurposing the antidiarrheal loperamide.

Yue L, Du J, Ye F, Chen Z, Li L, Lian F, Zhang B, Zhang Y, Jiang H, Chen K, Li Y, Zhou B, Zhang N, Yang Y, Luo C. Yue L, et al. Among authors: chen z, chen k. Org Biomol Chem. 2016 Sep 28;14(36):8503-19. doi: 10.1039/c6ob01248e. Epub 2016 Aug 19. Org Biomol Chem. 2016. PMID: 27541268

4

Discovery of novel BRD4 inhibitors by high-throughput screening, crystallography, and cell-based assays.

Sun Z, Zhang H, Chen Z, Xie Y, Jiang H, Chen L, Ding H, Zhang Y, Jiang H, Zheng M, Luo C. Sun Z, et al. Among authors: chen z, chen l. Bioorg Med Chem Lett. 2017 May 1;27(9):2003-2009. doi: 10.1016/j.bmcl.2017.03.012. Epub 2017 Mar 9. Bioorg Med Chem Lett. 2017. PMID: 28347667

5

Development of Potent Type I Protein Arginine Methyltransferase (PRMT) Inhibitors of Leukemia Cell Proliferation.

Wang C, Jiang H, Jin J, Xie Y, Chen Z, Zhang H, Lian F, Liu YC, Zhang C, Ding H, Chen S, Zhang N, Zhang Y, Jiang H, Chen K, Ye F, Yao Z, Luo C. Wang C, et al. Among authors: chen z, chen k, chen s. J Med Chem. 2017 Nov 9;60(21):8888-8905. doi: 10.1021/acs.jmedchem.7b01134. Epub 2017 Oct 27. J Med Chem. 2017. PMID: 29019697

6

Discovery of novel trimethoxy-ring BRD4 bromodomain inhibitors: AlphaScreen assay, crystallography and cell-based assay.

Chen Z, Zhang H, Liu S, Xie Y, Jiang H, Lu W, Xu H, Yue L, Zhang Y, Ding H, Zheng M, Yu K, Chen K, Jiang H, Luo C. Chen Z, et al. Among authors: chen k. Medchemcomm. 2017 Mar 17;8(6):1322-1331. doi: 10.1039/c7md00083a. eCollection 2017 Jun 1. Medchemcomm. 2017. PMID: 30108844 Free PMC article.

7

Identification of 5-benzylidene-2-phenylthiazolones as potent PRMT5 inhibitors by virtual screening, structural optimization and biological evaluations.

Zhu K, Tao H, Song JL, Jin L, Zhang Y, Liu J, Chen Z, Jiang CS, Luo C, Zhang H. Zhu K, et al. Among authors: chen z. Bioorg Chem. 2018 Dec;81:289-298. doi: 10.1016/j.bioorg.2018.08.021. Epub 2018 Aug 20. Bioorg Chem. 2018. PMID: 30172110

8

Discovery and biological evaluation of thiobarbituric derivatives as potent p300/CBP inhibitors.

Lu W, Xiong H, Chen Y, Wang C, Zhang H, Xu P, Han J, Xiao S, Ding H, Chen Z, Lu T, Wang J, Zhang Y, Yue L, Liu YC, Zhang C, Yang Y, Jiang H, Chen K, Zhou B, Luo C. Lu W, et al. Among authors: chen z, chen k, chen y. Bioorg Med Chem. 2018 Nov 1;26(20):5397-5407. doi: 10.1016/j.bmc.2018.07.048. Epub 2018 Jul 27. Bioorg Med Chem. 2018. PMID: 30297119

9

Development and evaluation of a novel series of Nitroxoline-derived BET inhibitors with antitumor activity in renal cell carcinoma.

Chen W, Zhang H, Chen Z, Jiang H, Liao L, Fan S, Xing J, Xie Y, Chen S, Ding H, Chen K, Jiang H, Luo C, Zheng M, Yao Z, Huang Y, Zhang Y. Chen W, et al. Among authors: chen z, chen k, chen s. Oncogenesis. 2018 Nov 2;7(11):83. doi: 10.1038/s41389-018-0093-z. Oncogenesis. 2018. PMID: 30385738 Free PMC article.

10

Discovery of 2-substituted-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide as potent and selective protein arginine methyltransferases 5 inhibitors: Design, synthesis and biological evaluation.

Shao J, Zhu K, Du D, Zhang Y, Tao H, Chen Z, Jiang H, Chen K, Luo C, Duan W. Shao J, et al. Among authors: chen z, chen k. Eur J Med Chem. 2019 Feb 15;164:317-333. doi: 10.1016/j.ejmech.2018.12.065. Epub 2018 Dec 26. Eur J Med Chem. 2019. PMID: 30605830

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