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Nanobodies effectively modulate the enzymatic activity of CD38 and allow specific imaging of CD38+ tumors in mouse models in vivo.
Fumey W, Koenigsdorf J, Kunick V, Menzel S, Schütze K, Unger M, Schriewer L, Haag F, Adam G, Oberle A, Binder M, Fliegert R, Guse A, Zhao YJ, Cheung Lee H, Malavasi F, Goldbaum F, van Hegelsom R, Stortelers C, Bannas P, Koch-Nolte F. Fumey W, et al. Among authors: kunick v. Sci Rep. 2017 Oct 30;7(1):14289. doi: 10.1038/s41598-017-14112-6. Sci Rep. 2017. PMID: 29084989 Free PMC article.
Molecular imaging of tumors with nanobodies and antibodies: Timing and dosage are crucial factors for improved in vivo detection.
Bannas P, Lenz A, Kunick V, Well L, Fumey W, Rissiek B, Haag F, Schmid J, Schütze K, Eichhoff A, Trepel M, Adam G, Ittrich H, Koch-Nolte F. Bannas P, et al. Among authors: kunick v. Contrast Media Mol Imaging. 2015 Sep-Oct;10(5):367-78. doi: 10.1002/cmmi.1637. Epub 2015 Apr 27. Contrast Media Mol Imaging. 2015. PMID: 25925493 Free article.