Dushek O - Search Results

1

Dynamic regulation of CD28 conformation and signaling by charged lipids and ions.

Yang W, Pan W, Chen S, Trendel N, Jiang S, Xiao F, Xue M, Wu W, Peng Z, Li X, Ji H, Liu X, Jiang H, Wang H, Shen H, Dushek O, Li H, Xu C. Yang W, et al. Among authors: dushek o. Nat Struct Mol Biol. 2017 Dec;24(12):1081-1092. doi: 10.1038/nsmb.3489. Epub 2017 Oct 23. Nat Struct Mol Biol. 2017. PMID: 29058713

2

Systems model of T cell receptor proximal signaling reveals emergent ultrasensitivity.

Mukhopadhyay H, Cordoba SP, Maini PK, van der Merwe PA, Dushek O. Mukhopadhyay H, et al. Among authors: dushek o. PLoS Comput Biol. 2013;9(3):e1003004. doi: 10.1371/journal.pcbi.1003004. Epub 2013 Mar 28. PLoS Comput Biol. 2013. PMID: 23555234 Free PMC article.

3

Architecture of a minimal signaling pathway explains the T-cell response to a 1 million-fold variation in antigen affinity and dose.

Lever M, Lim HS, Kruger P, Nguyen J, Trendel N, Abu-Shah E, Maini PK, van der Merwe PA, Dushek O. Lever M, et al. Among authors: dushek o. Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):E6630-E6638. doi: 10.1073/pnas.1608820113. Epub 2016 Oct 4. Proc Natl Acad Sci U S A. 2016. PMID: 27702900 Free PMC article.

4

Molecular mechanisms of T cell sensitivity to antigen.

Siller-Farfán JA, Dushek O. Siller-Farfán JA, et al. Among authors: dushek o. Immunol Rev. 2018 Sep;285(1):194-205. doi: 10.1111/imr.12690. Immunol Rev. 2018. PMID: 30129204 Review.

5

CD8 helps TCR catch slippery self pMHC.

Dushek O, Dustin ML. Dushek O, et al. Nat Immunol. 2018 Dec;19(12):1280-1281. doi: 10.1038/s41590-018-0261-5. Nat Immunol. 2018. PMID: 30420625 No abstract available.

6

Human CD8⁺ T Cells Exhibit a Shared Antigen Threshold for Different Effector Responses.

Abu-Shah E, Trendel N, Kruger P, Nguyen J, Pettmann J, Kutuzov M, Dushek O. Abu-Shah E, et al. Among authors: dushek o. J Immunol. 2020 Sep 15;205(6):1503-1512. doi: 10.4049/jimmunol.2000525. Epub 2020 Aug 17. J Immunol. 2020. PMID: 32817332 Free PMC article.

7

Perfect adaptation of CD8⁺ T cell responses to constant antigen input over a wide range of affinities is overcome by costimulation.

Trendel N, Kruger P, Gaglione S, Nguyen J, Pettmann J, Sontag ED, Dushek O. Trendel N, et al. Among authors: dushek o. Sci Signal. 2021 Jan 19;14(666):eaay9363. doi: 10.1126/scisignal.aay9363. Epub 2021 Jul 15. Sci Signal. 2021. PMID: 34855472 Free PMC article.

8

Dependence of T cell antigen recognition on T cell receptor-peptide MHC confinement time.

Aleksic M, Dushek O, Zhang H, Shenderov E, Chen JL, Cerundolo V, Coombs D, van der Merwe PA. Aleksic M, et al. Among authors: dushek o. Immunity. 2010 Feb 26;32(2):163-74. doi: 10.1016/j.immuni.2009.11.013. Epub 2010 Feb 4. Immunity. 2010. PMID: 20137987 Free PMC article.

9

Constitutively active Lck kinase in T cells drives antigen receptor signal transduction.

Nika K, Soldani C, Salek M, Paster W, Gray A, Etzensperger R, Fugger L, Polzella P, Cerundolo V, Dushek O, Höfer T, Viola A, Acuto O. Nika K, et al. Among authors: dushek o. Immunity. 2010 Jun 25;32(6):766-77. doi: 10.1016/j.immuni.2010.05.011. Epub 2010 Jun 11. Immunity. 2010. PMID: 20541955 Free PMC article.

10

Mechanisms for T cell receptor triggering.

van der Merwe PA, Dushek O. van der Merwe PA, et al. Among authors: dushek o. Nat Rev Immunol. 2011 Jan;11(1):47-55. doi: 10.1038/nri2887. Epub 2010 Dec 3. Nat Rev Immunol. 2011. PMID: 21127503 Review.

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