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Activation of IGF-1 receptors and Akt signaling by systemic hyperinsulinemia contributes to cardiac hypertrophy but does not regulate cardiac autophagy in obese diabetic mice.
Pires KM, Buffolo M, Schaaf C, David Symons J, Cox J, Abel ED, Selzman CH, Boudina S. Pires KM, et al. Among authors: david symons j. J Mol Cell Cardiol. 2017 Dec;113:39-50. doi: 10.1016/j.yjmcc.2017.10.001. Epub 2017 Oct 5. J Mol Cell Cardiol. 2017. PMID: 28987875 Free PMC article.