Abou-Gharbia M - Search Results

1

Polycyclic aryl- and heteroarylpiperazinyl imides as 5-HT1A receptor ligands and potential anxiolytic agents: synthesis and structure-activity relationship studies.

Abou-Gharbia M, Patel UR, Webb MB, Moyer JA, Andree TH, Muth EA. Abou-Gharbia M, et al. J Med Chem. 1988 Jul;31(7):1382-92. doi: 10.1021/jm00402a023. J Med Chem. 1988. PMID: 2898533

2

Synthesis and biological evaluation of benzodioxanylpiperazine derivatives as potent serotonin 5-HT(1A) antagonists: the discovery of Lecozotan.

Childers WE Jr, Abou-Gharbia MA, Kelly MG, Andree TH, Harrison BL, Ho DM, Hornby G, Huryn DM, Potestio L, Rosenzweig-Lipson SJ, Schmid J, Smith DL, Sukoff SJ, Zhang G, Schechter LE. Childers WE Jr, et al. J Med Chem. 2005 May 19;48(10):3467-70. doi: 10.1021/jm049493z. J Med Chem. 2005. PMID: 15887953

3

Synthesis and SAR of adatanserin: novel adamantyl aryl- and heteroarylpiperazines with dual serotonin 5-HT(1A) and 5-HT(2) activity as potential anxiolytic and antidepressant agents.

Abou-Gharbia MA, Childers WE Jr, Fletcher H, McGaughey G, Patel U, Webb MB, Yardley J, Andree T, Boast C, Kucharik RJ Jr, Marquis K, Morris H, Scerni R, Moyer JA. Abou-Gharbia MA, et al. J Med Chem. 1999 Dec 16;42(25):5077-94. doi: 10.1021/jm9806704. J Med Chem. 1999. PMID: 10602693

4

Synthesis and structure-activity relationship of substituted tetrahydro- and hexahydro-1,2-benzisothiazol-3-one 1,1-dioxides and thiadiazinones: potential anxiolytic agents.

Abou-Gharbia M, Moyer JA, Patel U, Webb M, Schiehser G, Andree T, Haskins JT. Abou-Gharbia M, et al. J Med Chem. 1989 May;32(5):1024-33. doi: 10.1021/jm00125a016. J Med Chem. 1989. PMID: 2565399

5

Psychotropic agents: synthesis and antipsychotic activity of substituted beta-carbolines.

Abou-Gharbia M, Patel UR, Moyer JA, Muth EA. Abou-Gharbia M, et al. J Med Chem. 1987 Jun;30(6):1100-5. doi: 10.1021/jm00389a022. J Med Chem. 1987. PMID: 2884314

6

Antipsychotic activity of substituted gamma-carbolines.

Abou-Gharbia M, Patel UR, Webb MB, Moyer JA, Andree TH, Muth EA. Abou-Gharbia M, et al. J Med Chem. 1987 Oct;30(10):1818-23. doi: 10.1021/jm00393a023. J Med Chem. 1987. PMID: 2888898

7

New antihistamines: substituted piperazine and piperidine derivatives as novel H1-antagonists.

Abou-Gharbia M, Moyer JA, Nielsen ST, Webb M, Patel U. Abou-Gharbia M, et al. J Med Chem. 1995 Sep 29;38(20):4026-32. doi: 10.1021/jm00020a018. J Med Chem. 1995. PMID: 7562938

8

New generation dopaminergic agents. 1. Discovery of a novel scaffold which embraces the D2 agonist pharmacophore. Structure-activity relationships of a series of 2-(aminomethyl)chromans.

Mewshaw RE, Kavanagh J, Stack G, Marquis KL, Shi X, Kagan MZ, Webb MB, Katz AH, Park A, Kang YH, Abou-Gharbia M, Scerni R, Wasik T, Cortes-Burgos L, Spangler T, Brennan JA, Piesla M, Mazandarani H, Cockett MI, Ochalski R, Coupet J, Andree TH. Mewshaw RE, et al. J Med Chem. 1997 Dec 19;40(26):4235-56. doi: 10.1021/jm9703653. J Med Chem. 1997. PMID: 9435894

9

New generation dopaminergic agents. 2. Discovery of 3-OH-phenoxyethylamine and 3-OH-N1-phenylpiperazine dopaminergic templates.

Mewshaw RE, Husbands M, Gildersleeve ES, Webb MB, Shi X, Mazandarani H, Cockett MI, Ochalski R, Brennan JA, Abou-Gharbia M, Marquis K, McGaughey GB, Coupet J, Andree TH. Mewshaw RE, et al. Bioorg Med Chem Lett. 1998 Feb 3;8(3):295-300. doi: 10.1016/s0960-894x(98)00014-6. Bioorg Med Chem Lett. 1998. PMID: 9871673

10

Design, synthesis, SAR, and biological evaluation of highly potent benzimidazole-spaced phosphono-alpha-amino acid competitive NMDA antagonists of the AP-6 type.

Baudy RB, Fletcher H 3rd, Yardley JP, Zaleska MM, Bramlett DR, Tasse RP, Kowal DM, Katz AH, Moyer JA, Abou-Gharbia M. Baudy RB, et al. J Med Chem. 2001 May 10;44(10):1516-29. doi: 10.1021/jm000385w. J Med Chem. 2001. PMID: 11334562

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