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Insulin resistance in brain alters dopamine turnover and causes behavioral disorders.
Kleinridders A, Cai W, Cappellucci L, Ghazarian A, Collins WR, Vienberg SG, Pothos EN, Kahn CR. Kleinridders A, et al. Among authors: cai w. Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):3463-8. doi: 10.1073/pnas.1500877112. Epub 2015 Mar 2. Proc Natl Acad Sci U S A. 2015. PMID: 25733901 Free PMC article.
Astrocytic Insulin Signaling Couples Brain Glucose Uptake with Nutrient Availability.
García-Cáceres C, Quarta C, Varela L, Gao Y, Gruber T, Legutko B, Jastroch M, Johansson P, Ninkovic J, Yi CX, Le Thuc O, Szigeti-Buck K, Cai W, Meyer CW, Pfluger PT, Fernandez AM, Luquet S, Woods SC, Torres-Alemán I, Kahn CR, Götz M, Horvath TL, Tschöp MH. García-Cáceres C, et al. Among authors: cai w. Cell. 2016 Aug 11;166(4):867-880. doi: 10.1016/j.cell.2016.07.028. Cell. 2016. PMID: 27518562 Free PMC article.
Insulin and IGF-1 receptors regulate FoxO-mediated signaling in muscle proteostasis.
O'Neill BT, Lee KY, Klaus K, Softic S, Krumpoch MT, Fentz J, Stanford KI, Robinson MM, Cai W, Kleinridders A, Pereira RO, Hirshman MF, Abel ED, Accili D, Goodyear LJ, Nair KS, Kahn CR. O'Neill BT, et al. Among authors: cai w. J Clin Invest. 2016 Sep 1;126(9):3433-46. doi: 10.1172/JCI86522. Epub 2016 Aug 15. J Clin Invest. 2016. PMID: 27525440 Free PMC article.
Insulin regulates astrocyte gliotransmission and modulates behavior.
Cai W, Xue C, Sakaguchi M, Konishi M, Shirazian A, Ferris HA, Li ME, Yu R, Kleinridders A, Pothos EN, Kahn CR. Cai W, et al. J Clin Invest. 2018 Jul 2;128(7):2914-2926. doi: 10.1172/JCI99366. Epub 2018 Jun 4. J Clin Invest. 2018. PMID: 29664737 Free PMC article.
TRPV1 neurons regulate β-cell function in a sex-dependent manner.
Bou Karam J, Cai W, Mohamed R, Huang T, Meng L, Homan EP, Dirice E, Kahn CR, El Ouaamari A. Bou Karam J, et al. Among authors: cai w. Mol Metab. 2018 Dec;18:60-67. doi: 10.1016/j.molmet.2018.10.002. Epub 2018 Oct 5. Mol Metab. 2018. PMID: 30473098 Free PMC article.
8,302 results