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A phase I open-label dose-escalation study of the anti-HER3 monoclonal antibody LJM716 in patients with advanced squamous cell carcinoma of the esophagus or head and neck and HER2-overexpressing breast or gastric cancer.
Reynolds KL, Bedard PL, Lee SH, Lin CC, Tabernero J, Alsina M, Cohen E, Baselga J, Blumenschein G Jr, Graham DM, Garrido-Laguna I, Juric D, Sharma S, Salgia R, Seroutou A, Tian X, Fernandez R, Morozov A, Sheng Q, Ramkumar T, Zubel A, Bang YJ. Reynolds KL, et al. Among authors: graham dm. BMC Cancer. 2017 Sep 12;17(1):646. doi: 10.1186/s12885-017-3641-6. BMC Cancer. 2017. PMID: 28899363 Free PMC article. Clinical Trial.
Latency and interval therapy affect the evolution in metastatic colorectal cancer.
Nikbakht H, Jessa S, Sukhai MA, Arseneault M, Zhang T, Letourneau L, Thomas M, Bourgey M, Roehrl MHA, Eveleigh R, Chen EX, Krzyzanowska M, Moore MJ, Giesler A, Yu C, Bedard PL, Kamel-Reid S, Majewski J, Siu LL, Riazalhosseini Y, Graham DM. Nikbakht H, et al. Among authors: graham dm. Sci Rep. 2020 Jan 17;10(1):581. doi: 10.1038/s41598-020-57476-y. Sci Rep. 2020. PMID: 31953485 Free PMC article.
A phase I study of binimetinib (MEK 162), a MEK inhibitor, plus carboplatin and pemetrexed chemotherapy in non-squamous non-small cell lung cancer.
Fung AS, Graham DM, Chen EX, Stockley TL, Zhang T, Le LW, Albaba H, Pisters KM, Bradbury PA, Trinkaus M, Chan M, Arif S, Zurawska U, Rothenstein J, Zawisza D, Effendi S, Gill S, Sawczak M, Law JH, Leighl NB. Fung AS, et al. Among authors: graham dm. Lung Cancer. 2021 Jul;157:21-29. doi: 10.1016/j.lungcan.2021.05.021. Epub 2021 May 24. Lung Cancer. 2021. PMID: 34052705 Clinical Trial.
Phase 1 trial design: is 3 + 3 the best?
Hansen AR, Graham DM, Pond GR, Siu LL. Hansen AR, et al. Among authors: graham dm. Cancer Control. 2014 Jul;21(3):200-8. doi: 10.1177/107327481402100304. Cancer Control. 2014. PMID: 24955703 Free article. Review.
161 results