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HLA-B*14:02-Restricted Env-Specific CD8+ T-Cell Activity Has Highly Potent Antiviral Efficacy Associated with Immune Control of HIV Infection.
Leitman EM, Willberg CB, Tsai MH, Chen H, Buus S, Chen F, Riddell L, Haas D, Fellay J, Goedert JJ, Piechocka-Trocha A, Walker BD, Martin J, Deeks S, Wolinsky SM, Martinson J, Martin M, Qi Y, Sáez-Cirión A, Yang OO, Matthews PC, Carrington M, Goulder PJR. Leitman EM, et al. Among authors: chen f, chen h. J Virol. 2017 Oct 27;91(22):e00544-17. doi: 10.1128/JVI.00544-17. Print 2017 Nov 15. J Virol. 2017. PMID: 28878089 Free PMC article. Clinical Trial.
Differential escape patterns within the dominant HLA-B*57:03-restricted HIV Gag epitope reflect distinct clade-specific functional constraints.
Payne RP, Branch S, Kløverpris H, Matthews PC, Koofhethile CK, Strong T, Adland E, Leitman E, Frater J, Ndung'u T, Hunter E, Haubrich R, Mothe B, Edwards A, Riddell L, Chen F, Harrigan PR, Brumme ZL, Mallal S, John M, Jooste JP, Shapiro R, Deeks SG, Walker BD, Brander C, Landis C, Carlson JM, Prado JG, Goulder PJ. Payne RP, et al. Among authors: chen f. J Virol. 2014 May;88(9):4668-78. doi: 10.1128/JVI.03303-13. Epub 2014 Feb 5. J Virol. 2014. PMID: 24501417 Free PMC article.
HIV control through a single nucleotide on the HLA-B locus.
Kløverpris HN, Harndahl M, Leslie AJ, Carlson JM, Ismail N, van der Stok M, Huang KH, Chen F, Riddell L, Steyn D, Goedhals D, van Vuuren C, Frater J, Walker BD, Carrington M, Ndung'u T, Buus S, Goulder P. Kløverpris HN, et al. Among authors: chen f. J Virol. 2012 Nov;86(21):11493-500. doi: 10.1128/JVI.01020-12. Epub 2012 Aug 15. J Virol. 2012. PMID: 22896606 Free PMC article.
Differential clade-specific HLA-B*3501 association with HIV-1 disease outcome is linked to immunogenicity of a single Gag epitope.
Matthews PC, Koyanagi M, Kløverpris HN, Harndahl M, Stryhn A, Akahoshi T, Gatanaga H, Oka S, Juarez Molina C, Valenzuela Ponce H, Avila Rios S, Cole D, Carlson J, Payne RP, Ogwu A, Bere A, Ndung'u T, Gounder K, Chen F, Riddell L, Luzzi G, Shapiro R, Brander C, Walker B, Sewell AK, Reyes Teran G, Heckerman D, Hunter E, Buus S, Takiguchi M, Goulder PJ. Matthews PC, et al. Among authors: chen f. J Virol. 2012 Dec;86(23):12643-54. doi: 10.1128/JVI.01381-12. Epub 2012 Sep 12. J Virol. 2012. PMID: 22973023 Free PMC article.
Early antigen presentation of protective HIV-1 KF11Gag and KK10Gag epitopes from incoming viral particles facilitates rapid recognition of infected cells by specific CD8+ T cells.
Kløverpris HN, Payne RP, Sacha JB, Rasaiyaah JT, Chen F, Takiguchi M, Yang OO, Towers GJ, Goulder P, Prado JG. Kløverpris HN, et al. Among authors: chen f. J Virol. 2013 Mar;87(5):2628-38. doi: 10.1128/JVI.02131-12. Epub 2012 Dec 19. J Virol. 2013. PMID: 23255798 Free PMC article.
Nef-specific CD8+ T cell responses contribute to HIV-1 immune control.
Adland E, Carlson JM, Paioni P, Kløverpris H, Shapiro R, Ogwu A, Riddell L, Luzzi G, Chen F, Balachandran T, Heckerman D, Stryhn A, Edwards A, Ndung'u T, Walker BD, Buus S, Goulder P, Matthews PC. Adland E, et al. Among authors: chen f. PLoS One. 2013 Sep 2;8(9):e73117. doi: 10.1371/journal.pone.0073117. eCollection 2013. PLoS One. 2013. PMID: 24023819 Free PMC article.
CD8+ TCR Bias and Immunodominance in HIV-1 Infection.
Kløverpris HN, McGregor R, McLaren JE, Ladell K, Harndahl M, Stryhn A, Carlson JM, Koofhethile C, Gerritsen B, Keşmir C, Chen F, Riddell L, Luzzi G, Leslie A, Walker BD, Ndung'u T, Buus S, Price DA, Goulder PJ. Kløverpris HN, et al. Among authors: chen f. J Immunol. 2015 Jun 1;194(11):5329-45. doi: 10.4049/jimmunol.1400854. Epub 2015 Apr 24. J Immunol. 2015. PMID: 25911754 Free PMC article.
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