Barran PE - Search Results

1

Uncoupling conformational states from activity in an allosteric enzyme.

Pisco JP, de Chiara C, Pacholarz KJ, Garza-Garcia A, Ogrodowicz RW, Walker PA, Barran PE, Smerdon SJ, de Carvalho LPS. Pisco JP, et al. Among authors: barran pe. Nat Commun. 2017 Aug 7;8(1):203. doi: 10.1038/s41467-017-00224-0. Nat Commun. 2017. PMID: 28781362 Free PMC article.

2

Mass spectrometry based tools to investigate protein-ligand interactions for drug discovery.

Pacholarz KJ, Garlish RA, Taylor RJ, Barran PE. Pacholarz KJ, et al. Among authors: barran pe. Chem Soc Rev. 2012 Jun 7;41(11):4335-55. doi: 10.1039/c2cs35035a. Epub 2012 Apr 24. Chem Soc Rev. 2012. PMID: 22532017 Review.

3

Dynamics of intact immunoglobulin G explored by drift-tube ion-mobility mass spectrometry and molecular modeling.

Pacholarz KJ, Porrini M, Garlish RA, Burnley RJ, Taylor RJ, Henry AJ, Barran PE. Pacholarz KJ, et al. Among authors: barran pe. Angew Chem Int Ed Engl. 2014 Jul 21;53(30):7765-9. doi: 10.1002/anie.201402863. Epub 2014 Jun 10. Angew Chem Int Ed Engl. 2014. PMID: 24916519

4

A mass-spectrometry-based framework to define the extent of disorder in proteins.

Beveridge R, Covill S, Pacholarz KJ, Kalapothakis JM, MacPhee CE, Barran PE. Beveridge R, et al. Among authors: barran pe. Anal Chem. 2014 Nov 18;86(22):10979-91. doi: 10.1021/ac5027435. Epub 2014 Oct 29. Anal Chem. 2014. PMID: 25353392

5

Insights into the conformations of three structurally diverse proteins: cytochrome c, p53, and MDM2, provided by variable-temperature ion mobility mass spectrometry.

Dickinson ER, Jurneczko E, Pacholarz KJ, Clarke DJ, Reeves M, Ball KL, Hupp T, Campopiano D, Nikolova PV, Barran PE. Dickinson ER, et al. Among authors: barran pe. Anal Chem. 2015 Mar 17;87(6):3231-8. doi: 10.1021/ac503720v. Epub 2015 Feb 25. Anal Chem. 2015. PMID: 25629302

6

Distinguishing Loss of Structure from Subunit Dissociation for Protein Complexes with Variable Temperature Ion Mobility Mass Spectrometry.

Pacholarz KJ, Barran PE. Pacholarz KJ, et al. Among authors: barran pe. Anal Chem. 2015 Jun 16;87(12):6271-9. doi: 10.1021/acs.analchem.5b01063. Epub 2015 Jun 3. Anal Chem. 2015. PMID: 25993423

7

Molecular Insights into the Thermal Stability of mAbs with Variable-Temperature Ion-Mobility Mass Spectrometry.

Pacholarz KJ, Peters SJ, Garlish RA, Henry AJ, Taylor RJ, Humphreys DP, Barran PE. Pacholarz KJ, et al. Among authors: barran pe. Chembiochem. 2016 Jan 1;17(1):46-51. doi: 10.1002/cbic.201500574. Epub 2015 Dec 3. Chembiochem. 2016. PMID: 26534882

8

Mass spectrometry locates local and allosteric conformational changes that occur on cofactor binding.

Beveridge R, Migas LG, Payne KAP, Scrutton NS, Leys D, Barran PE. Beveridge R, et al. Among authors: barran pe. Nat Commun. 2016 Jul 15;7:12163. doi: 10.1038/ncomms12163. Nat Commun. 2016. PMID: 27418477 Free PMC article.

9

Hybrid Mass Spectrometry Approaches to Determine How L-Histidine Feedback Regulates the Enzyzme MtATP-Phosphoribosyltransferase.

Pacholarz KJ, Burnley RJ, Jowitt TA, Ordsmith V, Pisco JP, Porrini M, Larrouy-Maumus G, Garlish RA, Taylor RJ, de Carvalho LPS, Barran PE. Pacholarz KJ, et al. Among authors: barran pe. Structure. 2017 May 2;25(5):730-738.e4. doi: 10.1016/j.str.2017.03.005. Epub 2017 Apr 6. Structure. 2017. PMID: 28392260 Free PMC article.

10

Charge Mediated Compaction and Rearrangement of Gas-Phase Proteins: A Case Study Considering Two Proteins at Opposing Ends of the Structure-Disorder Continuum.

Jhingree JR, Bellina B, Pacholarz KJ, Barran PE. Jhingree JR, et al. Among authors: barran pe. J Am Soc Mass Spectrom. 2017 Jul;28(7):1450-1461. doi: 10.1007/s13361-017-1692-1. Epub 2017 Jun 5. J Am Soc Mass Spectrom. 2017. PMID: 28585116 Free PMC article.

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