Savinainen JR - Search Results

1

Design, synthesis, and biological evaluation of 2,4-dihydropyrano[2,3-c]pyrazole derivatives as autotaxin inhibitors.

Pantsar T, Singha P, Nevalainen TJ, Koshevoy I, Leppänen J, Poso A, Niskanen JMA, Pasonen-Seppänen S, Savinainen JR, Laitinen T, Laitinen JT. Pantsar T, et al. Among authors: savinainen jr. Eur J Pharm Sci. 2017 Sep 30;107:97-111. doi: 10.1016/j.ejps.2017.07.002. Epub 2017 Jul 5. Eur J Pharm Sci. 2017. PMID: 28687529

2

Effects of topical anandamide-transport inhibitors, AM404 and olvanil, on intraocular pressure in normotensive rabbits.

Laine K, Järvinen T, Savinainen J, Laitinen JT, Pate DW, Järvinen K. Laine K, et al. Pharm Res. 2001 Apr;18(4):494-9. doi: 10.1023/a:1011058411804. Pharm Res. 2001. PMID: 11451037

3

Despite substantial degradation, 2-arachidonoylglycerol is a potent full efficacy agonist mediating CB(1) receptor-dependent G-protein activation in rat cerebellar membranes.

Savinainen JR, Järvinen T, Laine K, Laitinen JT. Savinainen JR, et al. Br J Pharmacol. 2001 Oct;134(3):664-72. doi: 10.1038/sj.bjp.0704297. Br J Pharmacol. 2001. PMID: 11588122 Free PMC article.

4

An optimized approach to study endocannabinoid signaling: evidence against constitutive activity of rat brain adenosine A1 and cannabinoid CB1 receptors.

Savinainen JR, Saario SM, Niemi R, Järvinen T, Laitinen JT. Savinainen JR, et al. Br J Pharmacol. 2003 Dec;140(8):1451-9. doi: 10.1038/sj.bjp.0705577. Epub 2003 Nov 17. Br J Pharmacol. 2003. PMID: 14623770 Free PMC article.

5

Monoglyceride lipase-like enzymatic activity is responsible for hydrolysis of 2-arachidonoylglycerol in rat cerebellar membranes.

Saario SM, Savinainen JR, Laitinen JT, Järvinen T, Niemi R. Saario SM, et al. Among authors: savinainen jr. Biochem Pharmacol. 2004 Apr 1;67(7):1381-7. doi: 10.1016/j.bcp.2003.12.003. Biochem Pharmacol. 2004. PMID: 15013854

6

Synthesis and CB1 receptor activities of novel arachidonyl alcohol derivatives.

Parkkari T, Savinainen JR, Rauhala AL, Tolonen TL, Nevalainen T, Laitinen JT, Gynther J, Järvinen T. Parkkari T, et al. Among authors: savinainen jr. Bioorg Med Chem Lett. 2004 Jun 21;14(12):3231-4. doi: 10.1016/j.bmcl.2004.03.093. Bioorg Med Chem Lett. 2004. PMID: 15149681

7

Detection of cannabinoid CB1, adenosine A1, muscarinic acetylcholine, and GABA(B) receptor-dependent G protein activity in transducin-deactivated membranes and autoradiography sections of rat retina.

Savinainen JR, Laitinen JT. Savinainen JR, et al. Cell Mol Neurobiol. 2004 Apr;24(2):243-56. doi: 10.1023/b:cemn.0000018619.18631.53. Cell Mol Neurobiol. 2004. PMID: 15176438

8

S-nitrosothiols modulate G protein-coupled receptor signaling in a reversible and highly receptor-specific manner.

Kokkola T, Savinainen JR, Mönkkönen KS, Retamal MD, Laitinen JT. Kokkola T, et al. Among authors: savinainen jr. BMC Cell Biol. 2005 Apr 25;6(1):21. doi: 10.1186/1471-2121-6-21. BMC Cell Biol. 2005. PMID: 15850493 Free PMC article.

9

Identification of WIN55212-3 as a competitive neutral antagonist of the human cannabinoid CB2 receptor.

Savinainen JR, Kokkola T, Salo OM, Poso A, Järvinen T, Laitinen JT. Savinainen JR, et al. Br J Pharmacol. 2005 Jul;145(5):636-45. doi: 10.1038/sj.bjp.0706230. Br J Pharmacol. 2005. PMID: 15852035 Free PMC article.

10

Virtual screening of novel CB2 ligands using a comparative model of the human cannabinoid CB2 receptor.

Salo OM, Raitio KH, Savinainen JR, Nevalainen T, Lahtela-Kakkonen M, Laitinen JT, Järvinen T, Poso A. Salo OM, et al. Among authors: savinainen jr. J Med Chem. 2005 Nov 17;48(23):7166-71. doi: 10.1021/jm050565b. J Med Chem. 2005. PMID: 16279774

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