Ramsden D - Search Results

1

Considerations from the IQ Induction Working Group in Response to Drug-Drug Interaction Guidance from Regulatory Agencies: Focus on Downregulation, CYP2C Induction, and CYP2B6 Positive Control.

Hariparsad N, Ramsden D, Palamanda J, Dekeyser JG, Fahmi OA, Kenny JR, Einolf H, Mohutsky M, Pardon M, Siu YA, Chen L, Sinz M, Jones B, Walsky R, Dallas S, Balani SK, Zhang G, Buckley D, Tweedie D. Hariparsad N, et al. Among authors: ramsden d. Drug Metab Dispos. 2017 Oct;45(10):1049-1059. doi: 10.1124/dmd.116.074567. Epub 2017 Jun 23. Drug Metab Dispos. 2017. PMID: 28646080

2

Enzyme-transporter interplay in the formation and clearance of abundant metabolites of faldaprevir found in excreta but not in circulation.

Li Y, Zhou J, Ramsden D, Taub ME, O'Brien D, Xu J, Busacca CA, Gonnella N, Tweedie DJ. Li Y, et al. Among authors: ramsden d. Drug Metab Dispos. 2014 Mar;42(3):384-93. doi: 10.1124/dmd.113.055863. Epub 2013 Dec 17. Drug Metab Dispos. 2014. PMID: 24346834

3

Bridging in vitro and in vivo metabolism and transport of faldaprevir in human using a novel cocultured human hepatocyte system, HepatoPac.

Ramsden D, Tweedie DJ, Chan TS, Taub ME, Li Y. Ramsden D, et al. Drug Metab Dispos. 2014 Mar;42(3):394-406. doi: 10.1124/dmd.113.055897. Epub 2013 Dec 23. Drug Metab Dispos. 2014. PMID: 24366904

4

Generating an in vitro-in vivo correlation for metabolism and liver enrichment of a hepatitis C virus drug, faldaprevir, using a rat hepatocyte model (HepatoPac).

Ramsden D, Tweedie DJ, St George R, Chen LZ, Li Y. Ramsden D, et al. Drug Metab Dispos. 2014 Mar;42(3):407-14. doi: 10.1124/dmd.113.055947. Epub 2013 Dec 23. Drug Metab Dispos. 2014. PMID: 24366905

5

Altered CYP2C9 activity following modulation of CYP3A4 levels in human hepatocytes: an example of protein-protein interactions.

Ramsden D, Tweedie DJ, Chan TS, Tracy TS. Ramsden D, et al. Drug Metab Dispos. 2014 Nov;42(11):1940-6. doi: 10.1124/dmd.114.057901. Epub 2014 Aug 25. Drug Metab Dispos. 2014. PMID: 25157098 Free PMC article.

6

Determination of a Degradation Constant for CYP3A4 by Direct Suppression of mRNA in a Novel Human Hepatocyte Model, HepatoPac.

Ramsden D, Zhou J, Tweedie DJ. Ramsden D, et al. Drug Metab Dispos. 2015 Sep;43(9):1307-15. doi: 10.1124/dmd.115.065326. Epub 2015 Jun 15. Drug Metab Dispos. 2015. PMID: 26076693

7

Contribution of Major Metabolites toward Complex Drug-Drug Interactions of Deleobuvir: In Vitro Predictions and In Vivo Outcomes.

Sane RS, Ramsden D, Sabo JP, Cooper C, Rowland L, Ting N, Whitcher-Johnstone A, Tweedie DJ. Sane RS, et al. Among authors: ramsden d. Drug Metab Dispos. 2016 Mar;44(3):466-75. doi: 10.1124/dmd.115.066985. Epub 2015 Dec 18. Drug Metab Dispos. 2016. PMID: 26684498

8

Evaluation of CYP2B6 Induction and Prediction of Clinical Drug-Drug Interactions: Considerations from the IQ Consortium Induction Working Group-An Industry Perspective.

Fahmi OA, Shebley M, Palamanda J, Sinz MW, Ramsden D, Einolf HJ, Chen L, Wang H. Fahmi OA, et al. Among authors: ramsden d. Drug Metab Dispos. 2016 Oct;44(10):1720-30. doi: 10.1124/dmd.116.071076. Epub 2016 Jul 15. Drug Metab Dispos. 2016. PMID: 27422672 Free PMC article.

9

Considerations from the Innovation and Quality Induction Working Group in Response to Drug-Drug Interaction Guidances from Regulatory Agencies: Focus on CYP3A4 mRNA In Vitro Response Thresholds, Variability, and Clinical Relevance.

Kenny JR, Ramsden D, Buckley DB, Dallas S, Fung C, Mohutsky M, Einolf HJ, Chen L, Dekeyser JG, Fitzgerald M, Goosen TC, Siu YA, Walsky RL, Zhang G, Tweedie D, Hariparsad N. Kenny JR, et al. Among authors: ramsden d. Drug Metab Dispos. 2018 Sep;46(9):1285-1303. doi: 10.1124/dmd.118.081927. Epub 2018 Jun 29. Drug Metab Dispos. 2018. PMID: 29959133

10

Identification and Characterization of a Selective Human Carbonyl Reductase 1 Substrate.

Ramsden D, Smith D, Arenas R, Frederick K, Cerny MA. Ramsden D, et al. Drug Metab Dispos. 2018 Oct;46(10):1434-1440. doi: 10.1124/dmd.118.082487. Epub 2018 Aug 1. Drug Metab Dispos. 2018. PMID: 30068520

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

367 results

Search Page

Filters