Engel ME - Search Results

1

Interlaboratory evaluation of a multiplexed high information content in vitro genotoxicity assay.

Bryce SM, Bernacki DT, Bemis JC, Spellman RA, Engel ME, Schuler M, Lorge E, Heikkinen PT, Hemmann U, Thybaud V, Wilde S, Queisser N, Sutter A, Zeller A, Guérard M, Kirkland D, Dertinger SD. Bryce SM, et al. Among authors: engel me. Environ Mol Mutagen. 2017 Apr;58(3):146-161. doi: 10.1002/em.22083. Environ Mol Mutagen. 2017. PMID: 28370322 Free PMC article.

2

Evaluation of phenolphthalein, diazepam and quinacrine dihydrochloride in the in vitro mammalian cell micronucleus test in Chinese hamster ovary (CHO) and TK6 cells.

Schuler M, Gudi R, Cheung J, Kumar S, Dickinson D, Engel M, Szkudlinska A, Colman M, Maduka N, Sherman J, Thiffeault C. Schuler M, et al. Mutat Res. 2010 Oct 29;702(2):219-29. doi: 10.1016/j.mrgentox.2010.04.004. Epub 2010 Apr 21. Mutat Res. 2010. PMID: 20399283

3

The rat gut micronucleus assay: a good choice for alternative in vivo genetic toxicology testing strategies.

Coffing S, Engel M, Dickinson D, Thiffeault C, Spellman R, Shutsky T, Schuler M. Coffing S, et al. Environ Mol Mutagen. 2011 May;52(4):269-79. doi: 10.1002/em.20616. Epub 2010 Sep 24. Environ Mol Mutagen. 2011. PMID: 20872852

4

Report on stage III Pig-a mutation assays using N-ethyl-N-nitrosourea-comparison with other in vivo genotoxicity endpoints.

Cammerer Z, Bhalli JA, Cao X, Coffing SL, Dickinson D, Dobo KL, Dobrovolsky VN, Engel M, Fiedler RD, Gunther WC, Heflich RH, Pearce MG, Shaddock JG, Shutsky T, Thiffeault CJ, Schuler M. Cammerer Z, et al. Environ Mol Mutagen. 2011 Dec;52(9):721-30. doi: 10.1002/em.20686. Environ Mol Mutagen. 2011. PMID: 22167886

5

Evaluation of the Pig-a, micronucleus, and comet assay endpoints in a 28-day study with ethyl methanesulfonate.

Gunther WC, Coffing SL, Dickinson DA, Engel ME, Fiedler RD, O'Lone SD, Sanok KE, Thiffeault CJ, Shutsky TJ, Schuler MJ, Dobo KL. Gunther WC, et al. Among authors: engel me. Environ Mol Mutagen. 2014 Jul;55(6):492-9. doi: 10.1002/em.21863. Epub 2014 Mar 6. Environ Mol Mutagen. 2014. PMID: 24599777

6

Experiments in the EpiDerm 3D Skin In Vitro Model and Minipigs In Vivo Indicate Comparatively Lower In Vivo Skin Sensitivity of Topically Applied Aneugenic Compounds.

Schuler M, Tomlinson L, Homiski M, Cheung J, Zhan Y, Coffing S, Engel M, Rubitski E, Seitis G, Hales K, Robertson A, Vispute S, Cook J, Radi Z, Hollingshead B. Schuler M, et al. Toxicol Sci. 2021 Feb 26;180(1):103-121. doi: 10.1093/toxsci/kfaa189. Toxicol Sci. 2021. PMID: 33481035

7

A new imaging platform (iScreen) allows for the concurrent assessment of micronucleus induction and genotoxic mode of action in human A375 cells.

Sun X, Rubitski E, Spellman RA, Engel M, Schuler M. Sun X, et al. Environ Mol Mutagen. 2022 Jun;63(5):230-245. doi: 10.1002/em.22496. Epub 2022 Jun 30. Environ Mol Mutagen. 2022. PMID: 35703118

8

Comparative analysis of micronucleus induction and DNA damage biomarkers in TK6 and A375 cells using flow cytometry.

Sun X, Spellman RA, Engel M, Rubitski E, Schuler M. Sun X, et al. Environ Mol Mutagen. 2024 Jan-Feb;65(1-2):25-46. doi: 10.1002/em.22585. Epub 2024 Feb 9. Environ Mol Mutagen. 2024. PMID: 38333939

9

Interlaboratory validation of the ToxTracker assay: An in vitro reporter assay for mechanistic genotoxicity assessment.

Hendriks G, Adriaens E, Allemang A, Clements J, Cole G, Derr R, Engel M, Hamel A, Kidd D, Kellum S, Kiyota T, Myhre A, Naëssens V, Pfuhler S, Roy M, Settivari R, Schuler M, Zeller A, van Benthem J, Vanparys P, Kirkland D. Hendriks G, et al. Environ Mol Mutagen. 2024 Jan-Feb;65(1-2):4-24. doi: 10.1002/em.22592. Epub 2024 Mar 28. Environ Mol Mutagen. 2024. PMID: 38545858

10

Practical and Science-Based Strategy for Establishing Acceptable Intakes for Drug Product N-Nitrosamine Impurities.

Dobo KL, Kenyon MO, Dirat O, Engel M, Fleetwood A, Martin M, Mattano S, Musso A, McWilliams JC, Papanikolaou A, Parris P, Whritenour J, Yu S, Kalgutkar AS. Dobo KL, et al. Chem Res Toxicol. 2022 Mar 21;35(3):475-489. doi: 10.1021/acs.chemrestox.1c00369. Epub 2022 Feb 25. Chem Res Toxicol. 2022. PMID: 35212515 Free PMC article.

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