Ursini-Siegel J - Search Results

1

The Shc1 adaptor simultaneously balances Stat1 and Stat3 activity to promote breast cancer immune suppression.

Ahn R, Sabourin V, Bolt AM, Hébert S, Totten S, De Jay N, Festa MC, Young YK, Im YK, Pawson T, Koromilas AE, Muller WJ, Mann KK, Kleinman CL, Ursini-Siegel J. Ahn R, et al. Nat Commun. 2017 Mar 9;8:14638. doi: 10.1038/ncomms14638. Nat Commun. 2017. PMID: 28276425 Free PMC article.

2

Insights from transgenic mouse models of ERBB2-induced breast cancer.

Ursini-Siegel J, Schade B, Cardiff RD, Muller WJ. Ursini-Siegel J, et al. Nat Rev Cancer. 2007 May;7(5):389-97. doi: 10.1038/nrc2127. Epub 2007 Apr 19. Nat Rev Cancer. 2007. PMID: 17446858 Review.

3

Elevated expression of DecR1 impairs ErbB2/Neu-induced mammary tumor development.

Ursini-Siegel J, Rajput AB, Lu H, Sanguin-Gendreau V, Zuo D, Papavasiliou V, Lavoie C, Turpin J, Cianflone K, Huntsman DG, Muller WJ. Ursini-Siegel J, et al. Mol Cell Biol. 2007 Sep;27(18):6361-71. doi: 10.1128/MCB.00686-07. Epub 2007 Jul 16. Mol Cell Biol. 2007. PMID: 17636013 Free PMC article.

4

ShcA signalling is essential for tumour progression in mouse models of human breast cancer.

Ursini-Siegel J, Hardy WR, Zuo D, Lam SH, Sanguin-Gendreau V, Cardiff RD, Pawson T, Muller WJ. Ursini-Siegel J, et al. EMBO J. 2008 Mar 19;27(6):910-20. doi: 10.1038/emboj.2008.22. Epub 2008 Feb 14. EMBO J. 2008. PMID: 18273058 Free PMC article.

5

The ShcA adaptor protein is a critical regulator of breast cancer progression.

Ursini-Siegel J, Muller WJ. Ursini-Siegel J, et al. Cell Cycle. 2008 Jul 1;7(13):1936-43. doi: 10.4161/cc.7.13.6205. Epub 2008 Apr 24. Cell Cycle. 2008. PMID: 18604176 Review.

6

Receptor tyrosine kinase signaling favors a protumorigenic state in breast cancer cells by inhibiting the adaptive immune response.

Ursini-Siegel J, Cory S, Zuo D, Hardy WR, Rexhepaj E, Lam S, Schade B, Jirstrom K, Bjur E, Piccirillo CA, Denardo D, Coussens LM, Brennan DJ, Gallagher WM, Park M, Pawson T, Hallett M, Muller WJ. Ursini-Siegel J, et al. Cancer Res. 2010 Oct 15;70(20):7776-87. doi: 10.1158/0008-5472.CAN-10-2229. Epub 2010 Oct 5. Cancer Res. 2010. PMID: 20924104 Free PMC article.

7

The ShcA SH2 domain engages a 14-3-3/PI3'K signaling complex and promotes breast cancer cell survival.

Ursini-Siegel J, Hardy WR, Zheng Y, Ling C, Zuo D, Zhang C, Podmore L, Pawson T, Muller WJ. Ursini-Siegel J, et al. Oncogene. 2012 Nov 29;31(48):5038-44. doi: 10.1038/onc.2012.4. Epub 2012 Jan 30. Oncogene. 2012. PMID: 22286768

8

The ShcA PTB domain functions as a biological sensor of phosphotyrosine signaling during breast cancer progression.

Ahn R, Sabourin V, Ha JR, Cory S, Maric G, Im YK, Hardy WR, Zhao H, Park M, Hallett M, Siegel PM, Pawson T, Ursini-Siegel J. Ahn R, et al. Cancer Res. 2013 Jul 15;73(14):4521-32. doi: 10.1158/0008-5472.CAN-12-4178. Epub 2013 May 21. Cancer Res. 2013. PMID: 23695548

9

The ShcA adaptor activates AKT signaling to potentiate breast tumor angiogenesis by stimulating VEGF mRNA translation in a 4E-BP-dependent manner.

Im YK, La Selva R, Gandin V, Ha JR, Sabourin V, Sonenberg N, Pawson T, Topisirovic I, Ursini-Siegel J. Im YK, et al. Oncogene. 2015 Mar 26;34(13):1729-35. doi: 10.1038/onc.2014.110. Epub 2014 May 19. Oncogene. 2015. PMID: 24837366

10

p66ShcA promotes breast cancer plasticity by inducing an epithelial-to-mesenchymal transition.

Hudson J, Ha JR, Sabourin V, Ahn R, La Selva R, Livingstone J, Podmore L, Knight J, Forrest L, Beauchemin N, Hallett M, Park M, Ursini-Siegel J. Hudson J, et al. Mol Cell Biol. 2014 Oct 1;34(19):3689-701. doi: 10.1128/MCB.00341-14. Epub 2014 Jul 28. Mol Cell Biol. 2014. PMID: 25071152 Free PMC article.

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