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A rare IL33 loss-of-function mutation reduces blood eosinophil counts and protects from asthma.
Smith D, Helgason H, Sulem P, Bjornsdottir US, Lim AC, Sveinbjornsson G, Hasegawa H, Brown M, Ketchem RR, Gavala M, Garrett L, Jonasdottir A, Jonasdottir A, Sigurdsson A, Magnusson OT, Eyjolfsson GI, Olafsson I, Onundarson PT, Sigurdardottir O, Gislason D, Gislason T, Ludviksson BR, Ludviksdottir D, Boezen HM, Heinzmann A, Krueger M, Porsbjerg C, Ahluwalia TS, Waage J, Backer V, Deichmann KA, Koppelman GH, Bønnelykke K, Bisgaard H, Masson G, Thorsteinsdottir U, Gudbjartsson DF, Johnston JA, Jonsdottir I, Stefansson K. Smith D, et al. PLoS Genet. 2017 Mar 8;13(3):e1006659. doi: 10.1371/journal.pgen.1006659. eCollection 2017 Mar. PLoS Genet. 2017. PMID: 28273074 Free PMC article.
High fractional exhaled nitric oxide and sputum eosinophils are associated with an increased risk of future virus-induced exacerbations: A prospective cohort study.
Bjerregaard A, Laing IA, Backer V, Sverrild A, Khoo SK, Chidlow G, Sikazwe C, Smith DW, Le Souëf P, Porsbjerg C. Bjerregaard A, et al. Among authors: smith dw. Clin Exp Allergy. 2017 Aug;47(8):1007-1013. doi: 10.1111/cea.12935. Epub 2017 May 9. Clin Exp Allergy. 2017. PMID: 28390083 Free PMC article. Clinical Trial.
Drug Repurposing: The Anthelmintics Niclosamide and Nitazoxanide Are Potent TMEM16A Antagonists That Fully Bronchodilate Airways.
Miner K, Labitzke K, Liu B, Wang P, Henckels K, Gaida K, Elliott R, Chen JJ, Liu L, Leith A, Trueblood E, Hensley K, Xia XZ, Homann O, Bennett B, Fiorino M, Whoriskey J, Yu G, Escobar S, Wong M, Born TL, Budelsky A, Comeau M, Smith D, Phillips J, Johnston JA, McGivern JG, Weikl K, Powers D, Kunzelmann K, Mohn D, Hochheimer A, Sullivan JK. Miner K, et al. Among authors: smith d. Front Pharmacol. 2019 Feb 14;10:51. doi: 10.3389/fphar.2019.00051. eCollection 2019. Front Pharmacol. 2019. PMID: 30837866 Free PMC article.
Research in progress: Medical Research Council United Kingdom Refractory Asthma Stratification Programme (RASP-UK).
Heaney LG, Djukanovic R, Woodcock A, Walker S, Matthews JG, Pavord ID, Bradding P, Niven R, Brightling CE, Chaudhuri R, Arron JR, Choy DF, Cowan D, Mansur A, Menzies-Gow A, Adcock I, Chung KF, Corrigan C, Coyle P, Harrison T, Johnston S, Howarth P, Lordan J, Sabroe I, Bigler J, Smith D, Catley M, May R, Pierre L, Stevenson C, Crater G, Keane F, Costello RW, Hudson V, Supple D, Hardman T. Heaney LG, et al. Among authors: smith d. Thorax. 2016 Feb;71(2):187-9. doi: 10.1136/thoraxjnl-2015-207326. Epub 2015 Jul 23. Thorax. 2016. PMID: 26205878 Free PMC article. Review.
Ed Focus on "Human Striatal Association Megaclusters".
Shen X, Smith DV. Shen X, et al. Among authors: smith dv. J Neurophysiol. 2024 Nov 6. doi: 10.1152/jn.00231.2024. Online ahead of print. J Neurophysiol. 2024. PMID: 39503584 No abstract available.
Emerging threat of artemisinin partial resistance markers (pfk13 mutations) in Plasmodium falciparum parasite populations in multiple geographical locations in high transmission regions of Uganda.
Agaba BB, Travis J, Smith D, Rugera SP, Zalwango MG, Opigo J, Katureebe C, Mpirirwe R, Bakary D, Antonio M, Khalid B, Ngonzi J, Kamya MR, Kaleebu P, Piot P, Cheng Q. Agaba BB, et al. Among authors: smith d. Malar J. 2024 Nov 5;23(1):330. doi: 10.1186/s12936-024-05158-9. Malar J. 2024. PMID: 39501325 Free PMC article.
Inno4Vac Workshop Report Part 1: Controlled Human Influenza Virus Infection Model (CHIVIM) Strain Selection and Immune Assays for CHIVIM Studies, November 2021, MHRA, UK.
Waldock J, Cox RJ, Chiu C, Subbarao K, Wildfire A, Barclay W, van Kasteren PB, McCauley J, Russell CA, Smith D, Thwaites RS, Tregoning JS, Engelhardt OG. Waldock J, et al. Among authors: smith d. Influenza Other Respir Viruses. 2024 Nov;18(11):e70014. doi: 10.1111/irv.70014. Influenza Other Respir Viruses. 2024. PMID: 39496425 Free PMC article. Review.
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