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A rare IL33 loss-of-function mutation reduces blood eosinophil counts and protects from asthma.
Smith D, Helgason H, Sulem P, Bjornsdottir US, Lim AC, Sveinbjornsson G, Hasegawa H, Brown M, Ketchem RR, Gavala M, Garrett L, Jonasdottir A, Jonasdottir A, Sigurdsson A, Magnusson OT, Eyjolfsson GI, Olafsson I, Onundarson PT, Sigurdardottir O, Gislason D, Gislason T, Ludviksson BR, Ludviksdottir D, Boezen HM, Heinzmann A, Krueger M, Porsbjerg C, Ahluwalia TS, Waage J, Backer V, Deichmann KA, Koppelman GH, Bønnelykke K, Bisgaard H, Masson G, Thorsteinsdottir U, Gudbjartsson DF, Johnston JA, Jonsdottir I, Stefansson K. Smith D, et al. Among authors: johnston ja. PLoS Genet. 2017 Mar 8;13(3):e1006659. doi: 10.1371/journal.pgen.1006659. eCollection 2017 Mar. PLoS Genet. 2017. PMID: 28273074 Free PMC article.
Differing roles for short chain fatty acids and GPR43 agonism in the regulation of intestinal barrier function and immune responses.
D'Souza WN, Douangpanya J, Mu S, Jaeckel P, Zhang M, Maxwell JR, Rottman JB, Labitzke K, Willee A, Beckmann H, Wang Y, Li Y, Schwandner R, Johnston JA, Towne JE, Hsu H. D'Souza WN, et al. Among authors: johnston ja. PLoS One. 2017 Jul 20;12(7):e0180190. doi: 10.1371/journal.pone.0180190. eCollection 2017. PLoS One. 2017. PMID: 28727837 Free PMC article.
Drug Repurposing: The Anthelmintics Niclosamide and Nitazoxanide Are Potent TMEM16A Antagonists That Fully Bronchodilate Airways.
Miner K, Labitzke K, Liu B, Wang P, Henckels K, Gaida K, Elliott R, Chen JJ, Liu L, Leith A, Trueblood E, Hensley K, Xia XZ, Homann O, Bennett B, Fiorino M, Whoriskey J, Yu G, Escobar S, Wong M, Born TL, Budelsky A, Comeau M, Smith D, Phillips J, Johnston JA, McGivern JG, Weikl K, Powers D, Kunzelmann K, Mohn D, Hochheimer A, Sullivan JK. Miner K, et al. Among authors: johnston ja. Front Pharmacol. 2019 Feb 14;10:51. doi: 10.3389/fphar.2019.00051. eCollection 2019. Front Pharmacol. 2019. PMID: 30837866 Free PMC article.
Risks of epilepsy.
Clarke J, Johnston JA. Clarke J, et al. Among authors: johnston ja. J Neurol. 2024 Sep 11. doi: 10.1007/s00415-024-12682-w. Online ahead of print. J Neurol. 2024. PMID: 39259303 No abstract available.
Incidence of type 2 diabetes, cardiovascular disease and chronic kidney disease in patients with multiple sclerosis initiating disease-modifying therapies: Retrospective cohort study using a frequentist model averaging statistical framework.
Brnabic AJM, Curtis SE, Johnston JA, Lo A, Zagar AJ, Lipkovich I, Kadziola Z, Murray MH, Ryan T. Brnabic AJM, et al. Among authors: johnston ja. PLoS One. 2024 Mar 22;19(3):e0300708. doi: 10.1371/journal.pone.0300708. eCollection 2024. PLoS One. 2024. PMID: 38517926 Free PMC article.
Quantitative measurement of the requirement of diverse protein degradation pathways in MHC class I peptide presentation.
Mamrosh JL, Sherman DJ, Cohen JR, Johnston JA, Joubert MK, Li J, Lipford JR, Lomenick B, Moradian A, Prabhu S, Sweredoski MJ, Vander Lugt B, Verma R, Deshaies RJ. Mamrosh JL, et al. Among authors: johnston ja. Sci Adv. 2023 Jun 23;9(25):eade7890. doi: 10.1126/sciadv.ade7890. Epub 2023 Jun 23. Sci Adv. 2023. PMID: 37352349 Free PMC article.
396 results