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Role of cytochrome P4501B1 in benzo[a]pyrene bioactivation to DNA-binding metabolites in mouse vascular smooth muscle cells: evidence from 32P-postlabeling for formation of 3-hydroxybenzo[a]pyrene and benzo[a]pyrene-3,6-quinone as major proximate genotoxic intermediates.
Moorthy B, Miller KP, Jiang W, Williams ES, Kondraganti SR, Ramos KS. Moorthy B, et al. J Pharmacol Exp Ther. 2003 Apr;305(1):394-401. doi: 10.1124/jpet.102.044271. J Pharmacol Exp Ther. 2003. PMID: 12649394
Disruption of the Ah receptor gene alters the susceptibility of mice to oxygen-mediated regulation of pulmonary and hepatic cytochromes P4501A expression and exacerbates hyperoxic lung injury.
Jiang W, Welty SE, Couroucli XI, Barrios R, Kondraganti SR, Muthiah K, Yu L, Avery SE, Moorthy B. Jiang W, et al. Among authors: moorthy b. J Pharmacol Exp Ther. 2004 Aug;310(2):512-9. doi: 10.1124/jpet.103.059766. Epub 2004 May 3. J Pharmacol Exp Ther. 2004. PMID: 15123765
180 results