Riccardi K - Search Results

1

Novel Method to Predict In Vivo Liver-to-Plasma K_puu for OATP Substrates Using Suspension Hepatocytes.

Riccardi K, Lin J, Li Z, Niosi M, Ryu S, Hua W, Atkinson K, Kosa RE, Litchfield J, Di L. Riccardi K, et al. Drug Metab Dispos. 2017 May;45(5):576-580. doi: 10.1124/dmd.116.074575. Epub 2017 Mar 3. Drug Metab Dispos. 2017. PMID: 28258068

2

Determination of Unbound Partition Coefficient and in Vitro-in Vivo Extrapolation for SLC13A Transporter-Mediated Uptake.

Riccardi K, Li Z, Brown JA, Gorgoglione MF, Niosi M, Gosset J, Huard K, Erion DM, Di L. Riccardi K, et al. Drug Metab Dispos. 2016 Oct;44(10):1633-42. doi: 10.1124/dmd.116.071837. Epub 2016 Jul 14. Drug Metab Dispos. 2016. PMID: 27417179

3

Comparison of Species and Cell-Type Differences in Fraction Unbound of Liver Tissues, Hepatocytes, and Cell Lines.

Riccardi K, Ryu S, Lin J, Yates P, Tess D, Li R, Singh D, Holder BR, Kapinos B, Chang G, Di L. Riccardi K, et al. Drug Metab Dispos. 2018 Apr;46(4):415-421. doi: 10.1124/dmd.117.079152. Epub 2018 Feb 2. Drug Metab Dispos. 2018. PMID: 29437874

4

6-Chloro-5-[4-(1-Hydroxycyclobutyl)Phenyl]-1H-Indole-3-Carboxylic Acid is a Highly Selective Substrate for Glucuronidation by UGT1A1, Relative to β-Estradiol.

Lapham K, Lin J, Novak J, Orozco C, Niosi M, Di L, Goosen TC, Ryu S, Riccardi K, Eng H, Cameron KO, Kalgutkar AS. Lapham K, et al. Among authors: riccardi k. Drug Metab Dispos. 2018 Dec;46(12):1836-1846. doi: 10.1124/dmd.118.083709. Epub 2018 Sep 7. Drug Metab Dispos. 2018. PMID: 30194276

5

Comparison of Fraction Unbound Between Liver Homogenate and Hepatocytes at 4°C.

Riccardi K, Ryu S, Tess D, Li R, Luo L, Johnson N, Jordan S, Patel R, Di L. Riccardi K, et al. AAPS J. 2020 Jul 15;22(4):91. doi: 10.1208/s12248-020-00476-7. AAPS J. 2020. PMID: 32671577

6

Evolving approaches on measurements and applications of intracellular free drug concentration and Kp_uu in drug discovery.

Di L, Riccardi K, Tess D. Di L, et al. Among authors: riccardi k. Expert Opin Drug Metab Toxicol. 2021 Jul;17(7):733-746. doi: 10.1080/17425255.2021.1935866. Epub 2021 Jul 22. Expert Opin Drug Metab Toxicol. 2021. PMID: 34058926 Review.

7

A Study on Pharmacokinetics of Bosentan with Systems Modeling, Part 1: Translating Systemic Plasma Concentration to Liver Exposure in Healthy Subjects.

Li R, Niosi M, Johnson N, Tess DA, Kimoto E, Lin J, Yang X, Riccardi KA, Ryu S, El-Kattan AF, Maurer TS, Tremaine LM, Di L. Li R, et al. Drug Metab Dispos. 2018 Apr;46(4):346-356. doi: 10.1124/dmd.117.078790. Epub 2018 Jan 12. Drug Metab Dispos. 2018. PMID: 29330218

8

A Novel Unified Approach to Predict Human Hepatic Clearance for Both Enzyme- and Transporter-Mediated Mechanisms Using Suspended Human Hepatocytes.

Riccardi KA, Tess DA, Lin J, Patel R, Ryu S, Atkinson K, Di L, Li R. Riccardi KA, et al. Drug Metab Dispos. 2019 May;47(5):484-492. doi: 10.1124/dmd.118.085639. Epub 2019 Feb 20. Drug Metab Dispos. 2019. PMID: 30787098

9

Plasma Protein Binding of Challenging Compounds.

Riccardi K, Cawley S, Yates PD, Chang C, Funk C, Niosi M, Lin J, Di L. Riccardi K, et al. J Pharm Sci. 2015 Aug;104(8):2627-36. doi: 10.1002/jps.24506. Epub 2015 Jun 2. J Pharm Sci. 2015. PMID: 26037784

10

Applying Two Orthogonal Methods to Assess Accuracy of Plasma Protein Binding Measurements for Highly Bound Compounds.

Ryu S, Riccardi K, Patel R, Zueva L, Burchett W, Di L. Ryu S, et al. Among authors: riccardi k. J Pharm Sci. 2019 Nov;108(11):3745-3749. doi: 10.1016/j.xphs.2019.08.004. Epub 2019 Aug 13. J Pharm Sci. 2019. PMID: 31419399

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