Kalgutkar AS - Search Results

1

Examination of the Human Cytochrome P4503A4 Induction Potential of PF-06282999, an Irreversible Myeloperoxidase Inactivator: Integration of Preclinical, In Silico, and Biomarker Methodologies in the Prediction of the Clinical Outcome.

Dong JQ, Gosset JR, Fahmi OA, Lin Z, Chabot JR, Terra SG, Le V, Chidsey K, Nouri P, Kim A, Buckbinder L, Kalgutkar AS. Dong JQ, et al. Among authors: kalgutkar as. Drug Metab Dispos. 2017 May;45(5):501-511. doi: 10.1124/dmd.116.074476. Epub 2017 Mar 2. Drug Metab Dispos. 2017. PMID: 28254951

2

Pharmacokinetics and metabolism of a cysteinyl leukotriene-1 receptor antagonist from the heterocyclic chromanol series in rats: in vitro-in vivo correlation, gender-related differences, isoform identification, and comparison with metabolism in human hepatic tissue.

Kuperman AV, Kalgutkar AS, Marfat A, Chambers RJ, Liston TE. Kuperman AV, et al. Among authors: kalgutkar as. Drug Metab Dispos. 2001 Nov;29(11):1403-9. Drug Metab Dispos. 2001. PMID: 11602515

3

Pharmacokinetics and metabolism of the reactive oxygen scavenger alpha-phenyl-N-tert-butylnitrone in the male Sprague-Dawley rat.

Trudeau-Lame ME, Kalgutkar AS, LaFontaine M. Trudeau-Lame ME, et al. Among authors: kalgutkar as. Drug Metab Dispos. 2003 Feb;31(2):147-52. doi: 10.1124/dmd.31.2.147. Drug Metab Dispos. 2003. PMID: 12527695

4

Assessment of the contributions of CYP3A4 and CYP3A5 in the metabolism of the antipsychotic agent haloperidol to its potentially neurotoxic pyridinium metabolite and effect of antidepressants on the bioactivation pathway.

Kalgutkar AS, Taylor TJ, Venkatakrishnan K, Isin EM. Kalgutkar AS, et al. Drug Metab Dispos. 2003 Mar;31(3):243-9. doi: 10.1124/dmd.31.3.243. Drug Metab Dispos. 2003. PMID: 12584149

5

Influence of lipophilicity on the interactions of N-alkyl-4-phenyl-1,2,3,6-tetrahydropyridines and their positively charged N-alkyl-4-phenylpyridinium metabolites with cytochrome P450 2D6.

Kalgutkar AS, Zhou S, Fahmi OA, Taylor TJ. Kalgutkar AS, et al. Drug Metab Dispos. 2003 May;31(5):596-605. doi: 10.1124/dmd.31.5.596. Drug Metab Dispos. 2003. PMID: 12695348

6

In vitro metabolism studies on the isoxazole ring scission in the anti-inflammatory agent lefluonomide to its active alpha-cyanoenol metabolite A771726: mechanistic similarities with the cytochrome P450-catalyzed dehydration of aldoximes.

Kalgutkar AS, Nguyen HT, Vaz AD, Doan A, Dalvie DK, McLeod DG, Murray JC. Kalgutkar AS, et al. Drug Metab Dispos. 2003 Oct;31(10):1240-50. doi: 10.1124/dmd.31.10.1240. Drug Metab Dispos. 2003. PMID: 12975333

7

Mechanism-based inactivation of human recombinant P450 2C9 by the nonsteroidal anti-inflammatory drug suprofen.

O'Donnell JP, Dalvie DK, Kalgutkar AS, Obach RS. O'Donnell JP, et al. Among authors: kalgutkar as. Drug Metab Dispos. 2003 Nov;31(11):1369-77. doi: 10.1124/dmd.31.11.1369. Drug Metab Dispos. 2003. PMID: 14570769

8

Identification of an N-methyl-4-phenylpyridinium-like metabolite of the antidiarrheal agent loperamide in human liver microsomes: underlying reason(s) for the lack of neurotoxicity despite the bioactivation event.

Kalgutkar AS, Nguyen HT. Kalgutkar AS, et al. Drug Metab Dispos. 2004 Sep;32(9):943-52. Drug Metab Dispos. 2004. PMID: 15319335

9

Bioactivation of the nontricyclic antidepressant nefazodone to a reactive quinone-imine species in human liver microsomes and recombinant cytochrome P450 3A4.

Kalgutkar AS, Vaz AD, Lame ME, Henne KR, Soglia J, Zhao SX, Abramov YA, Lombardo F, Collin C, Hendsch ZS, Hop CE. Kalgutkar AS, et al. Drug Metab Dispos. 2005 Feb;33(2):243-53. doi: 10.1124/dmd.104.001735. Epub 2004 Nov 2. Drug Metab Dispos. 2005. PMID: 15523046

10

Preclinical pharmacokinetics and metabolism of 6-(4-(2,5-difluorophenyl)oxazol-5-yl)-3-isopropyl-[1,2,4]-triazolo[4,3-a]pyridine, a novel and selective p38alpha inhibitor: identification of an active metabolite in preclinical species and human liver microsomes.

Kalgutkar AS, Hatch HL, Kosea F, Nguyen HT, Choo EF, McClure KF, Taylor TJ, Henne KR, Kuperman AV, Dombroski MA, Letavic MA. Kalgutkar AS, et al. Biopharm Drug Dispos. 2006 Nov;27(8):371-86. doi: 10.1002/bdd.520. Biopharm Drug Dispos. 2006. PMID: 16944451

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