MacLeod AR - Search Results

1

Depletion of coagulation factor XII ameliorates brain pathology and cognitive impairment in Alzheimer disease mice.

Chen ZL, Revenko AS, Singh P, MacLeod AR, Norris EH, Strickland S. Chen ZL, et al. Among authors: macleod ar. Blood. 2017 May 4;129(18):2547-2556. doi: 10.1182/blood-2016-11-753202. Epub 2017 Feb 27. Blood. 2017. PMID: 28242605 Free PMC article.

2

Selective depletion of plasma prekallikrein or coagulation factor XII inhibits thrombosis in mice without increased risk of bleeding.

Revenko AS, Gao D, Crosby JR, Bhattacharjee G, Zhao C, May C, Gailani D, Monia BP, MacLeod AR. Revenko AS, et al. Among authors: macleod ar. Blood. 2011 Nov 10;118(19):5302-11. doi: 10.1182/blood-2011-05-355248. Epub 2011 Aug 5. Blood. 2011. PMID: 21821705 Free PMC article.

3

Blood-derived plasminogen drives brain inflammation and plaque deposition in a mouse model of Alzheimer's disease.

Baker SK, Chen ZL, Norris EH, Revenko AS, MacLeod AR, Strickland S. Baker SK, et al. Among authors: macleod ar. Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):E9687-E9696. doi: 10.1073/pnas.1811172115. Epub 2018 Sep 25. Proc Natl Acad Sci U S A. 2018. PMID: 30254165 Free PMC article.

4

Inhibition of the intrinsic coagulation pathway factor XI by antisense oligonucleotides: a novel antithrombotic strategy with lowered bleeding risk.

Zhang H, Löwenberg EC, Crosby JR, MacLeod AR, Zhao C, Gao D, Black C, Revenko AS, Meijers JC, Stroes ES, Levi M, Monia BP. Zhang H, et al. Among authors: macleod ar. Blood. 2010 Nov 25;116(22):4684-92. doi: 10.1182/blood-2010-04-277798. Epub 2010 Aug 31. Blood. 2010. PMID: 20807891 Free article.

5

Inhibition of vascular permeability by antisense-mediated inhibition of plasma kallikrein and coagulation factor 12.

Bhattacharjee G, Revenko AS, Crosby JR, May C, Gao D, Zhao C, Monia BP, MacLeod AR. Bhattacharjee G, et al. Among authors: macleod ar. Nucleic Acid Ther. 2013 Jun;23(3):175-87. doi: 10.1089/nat.2013.0417. Epub 2013 Apr 12. Nucleic Acid Ther. 2013. PMID: 23582057

6

The contact system proteases play disparate roles in streptococcal sepsis.

Köhler J, Maletzki C, Koczan D, Frank M, Trepesch C, Revenko AS, Crosby JR, Macleod AR, Mikkat S, Oehmcke-Hecht S. Köhler J, et al. Among authors: macleod ar. Haematologica. 2020 May;105(5):1424-1435. doi: 10.3324/haematol.2019.223545. Epub 2019 Jul 18. Haematologica. 2020. PMID: 31320552 Free PMC article.

7

Antisense oligonucleotide targeting of thrombopoietin represents a novel platelet depletion method to assess the immunomodulatory role of platelets.

Barrett TJ, Wu BG, Revenko AS, MacLeod AR, Segal LN, Berger JS. Barrett TJ, et al. Among authors: macleod ar. J Thromb Haemost. 2020 Jul;18(7):1773-1782. doi: 10.1111/jth.14808. Epub 2020 May 6. J Thromb Haemost. 2020. PMID: 32227586 Free article.

8

Antithrombotic effect of antisense factor XI oligonucleotide treatment in primates.

Crosby JR, Marzec U, Revenko AS, Zhao C, Gao D, Matafonov A, Gailani D, MacLeod AR, Tucker EI, Gruber A, Hanson SR, Monia BP. Crosby JR, et al. Among authors: macleod ar. Arterioscler Thromb Vasc Biol. 2013 Jul;33(7):1670-8. doi: 10.1161/ATVBAHA.113.301282. Epub 2013 Apr 4. Arterioscler Thromb Vasc Biol. 2013. PMID: 23559626 Free PMC article.

9

IONIS-PKK_Rx a Novel Antisense Inhibitor of Prekallikrein and Bradykinin Production.

Ferrone JD, Bhattacharjee G, Revenko AS, Zanardi TA, Warren MS, Derosier FJ, Viney NJ, Pham NC, Kaeser GE, Baker BF, Schneider E, Hughes SG, Monia BP, MacLeod AR. Ferrone JD, et al. Among authors: macleod ar. Nucleic Acid Ther. 2019 Apr;29(2):82-91. doi: 10.1089/nat.2018.0754. Epub 2019 Feb 28. Nucleic Acid Ther. 2019. PMID: 30817230 Free PMC article.

10

Kininogen supports inflammation and bacterial spreading during Streptococccus Pyogenes Sepsis.

Köhler J, Maletzki C, Koczan D, Frank M, Springer A, Steffen C, Revenko AS, MacLeod AR, Mikkat S, Kreikemeyer B, Oehmcke-Hecht S. Köhler J, et al. Among authors: macleod ar. EBioMedicine. 2020 Aug;58:102908. doi: 10.1016/j.ebiom.2020.102908. Epub 2020 Jul 21. EBioMedicine. 2020. PMID: 32707450 Free PMC article.

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