Lazarus RA - Search Results

1

Taming hyperactive hDNase I: Stable inducible expression of a hyperactive salt- and actin-resistant variant of human deoxyribonuclease I in CHO cells.

Lam C, Santell L, Wilson B, Yim M, Louie S, Tang D, Shaw D, Chan P, Lazarus RA, Snedecor B, Misaghi S. Lam C, et al. Among authors: lazarus ra. Biotechnol Prog. 2017 Mar;33(2):523-533. doi: 10.1002/btpr.2439. Epub 2017 Feb 6. Biotechnol Prog. 2017. PMID: 28127892

2

Engineering actin-resistant human DNase I for treatment of cystic fibrosis.

Ulmer JS, Herzka A, Toy KJ, Baker DL, Dodge AH, Sinicropi D, Shak S, Lazarus RA. Ulmer JS, et al. Among authors: lazarus ra. Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8225-9. doi: 10.1073/pnas.93.16.8225. Proc Natl Acad Sci U S A. 1996. PMID: 8710851 Free PMC article.

3

Engineering hyperactive variants of human deoxyribonuclease I by altering its functional mechanism.

Pan CQ, Lazarus RA. Pan CQ, et al. Among authors: lazarus ra. Biochemistry. 1997 Jun 3;36(22):6624-32. doi: 10.1021/bi962960x. Biochemistry. 1997. PMID: 9184142

4

Improved potency of hyperactive and actin-resistant human DNase I variants for treatment of cystic fibrosis and systemic lupus erythematosus.

Pan CQ, Dodge TH, Baker DL, Prince WS, Sinicropi DV, Lazarus RA. Pan CQ, et al. Among authors: lazarus ra. J Biol Chem. 1998 Jul 17;273(29):18374-81. doi: 10.1074/jbc.273.29.18374. J Biol Chem. 1998. PMID: 9660804 Free article.

5

Peptide exosite inhibitors of factor VIIa as anticoagulants.

Dennis MS, Eigenbrot C, Skelton NJ, Ultsch MH, Santell L, Dwyer MA, O'Connell MP, Lazarus RA. Dennis MS, et al. Among authors: lazarus ra. Nature. 2000 Mar 30;404(6777):465-70. doi: 10.1038/35006574. Nature. 2000. PMID: 10761907

6

The factor VII zymogen structure reveals reregistration of beta strands during activation.

Eigenbrot C, Kirchhofer D, Dennis MS, Santell L, Lazarus RA, Stamos J, Ultsch MH. Eigenbrot C, et al. Among authors: lazarus ra. Structure. 2001 Jul 3;9(7):627-36. doi: 10.1016/s0969-2126(01)00624-4. Structure. 2001. PMID: 11470437 Free article.

7

A novel exosite on coagulation factor VIIa and its molecular interactions with a new class of peptide inhibitors.

Roberge M, Santell L, Dennis MS, Eigenbrot C, Dwyer MA, Lazarus RA. Roberge M, et al. Among authors: lazarus ra. Biochemistry. 2001 Aug 14;40(32):9522-31. doi: 10.1021/bi010592d. Biochemistry. 2001. PMID: 11583151

8

Structural and functional basis of the serine protease-like hepatocyte growth factor beta-chain in Met binding and signaling.

Kirchhofer D, Yao X, Peek M, Eigenbrot C, Lipari MT, Billeci KL, Maun HR, Moran P, Santell L, Wiesmann C, Lazarus RA. Kirchhofer D, et al. Among authors: lazarus ra. J Biol Chem. 2004 Sep 17;279(38):39915-24. doi: 10.1074/jbc.M404795200. Epub 2004 Jun 24. J Biol Chem. 2004. PMID: 15218027 Free article.

9

Conformational lability in serine protease active sites: structures of hepatocyte growth factor activator (HGFA) alone and with the inhibitory domain from HGFA inhibitor-1B.

Shia S, Stamos J, Kirchhofer D, Fan B, Wu J, Corpuz RT, Santell L, Lazarus RA, Eigenbrot C. Shia S, et al. Among authors: lazarus ra. J Mol Biol. 2005 Mar 11;346(5):1335-49. doi: 10.1016/j.jmb.2004.12.048. Epub 2005 Jan 28. J Mol Biol. 2005. PMID: 15713485

10

Utilizing the activation mechanism of serine proteases to engineer hepatocyte growth factor into a Met antagonist.

Kirchhofer D, Lipari MT, Santell L, Billeci KL, Maun HR, Sandoval WN, Moran P, Ridgway J, Eigenbrot C, Lazarus RA. Kirchhofer D, et al. Among authors: lazarus ra. Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5306-11. doi: 10.1073/pnas.0700184104. Epub 2007 Mar 19. Proc Natl Acad Sci U S A. 2007. PMID: 17372204 Free PMC article.

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