Mandelkow E - Search Results

1

A Two-Component Adhesive: Tau Fibrils Arise from a Combination of a Well-Defined Motif and Conformationally Flexible Interactions.

Xiang S, Kulminskaya N, Habenstein B, Biernat J, Tepper K, Paulat M, Griesinger C, Becker S, Lange A, Mandelkow E, Linser R. Xiang S, et al. Among authors: mandelkow e. J Am Chem Soc. 2017 Feb 22;139(7):2639-2646. doi: 10.1021/jacs.6b09619. Epub 2017 Feb 8. J Am Chem Soc. 2017. PMID: 28124562

2

Protein kinase MARK/PAR-1 is required for neurite outgrowth and establishment of neuronal polarity.

Biernat J, Wu YZ, Timm T, Zheng-Fischhöfer Q, Mandelkow E, Meijer L, Mandelkow EM. Biernat J, et al. Among authors: mandelkow em, mandelkow e. Mol Biol Cell. 2002 Nov;13(11):4013-28. doi: 10.1091/mbc.02-03-0046. Mol Biol Cell. 2002. PMID: 12429843 Free PMC article.

3

MARKK, a Ste20-like kinase, activates the polarity-inducing kinase MARK/PAR-1.

Timm T, Li XY, Biernat J, Jiao J, Mandelkow E, Vandekerckhove J, Mandelkow EM. Timm T, et al. Among authors: mandelkow em, mandelkow e. EMBO J. 2003 Oct 1;22(19):5090-101. doi: 10.1093/emboj/cdg447. EMBO J. 2003. PMID: 14517247 Free PMC article.

4

Anthraquinones inhibit tau aggregation and dissolve Alzheimer's paired helical filaments in vitro and in cells.

Pickhardt M, Gazova Z, von Bergen M, Khlistunova I, Wang Y, Hascher A, Mandelkow EM, Biernat J, Mandelkow E. Pickhardt M, et al. Among authors: mandelkow em, mandelkow e. J Biol Chem. 2005 Feb 4;280(5):3628-35. doi: 10.1074/jbc.M410984200. Epub 2004 Nov 2. J Biol Chem. 2005. PMID: 15525637 Free article.

5

Tau aggregation is driven by a transition from random coil to beta sheet structure.

von Bergen M, Barghorn S, Biernat J, Mandelkow EM, Mandelkow E. von Bergen M, et al. Among authors: mandelkow em, mandelkow e. Biochim Biophys Acta. 2005 Jan 3;1739(2-3):158-66. doi: 10.1016/j.bbadis.2004.09.010. Epub 2004 Nov 12. Biochim Biophys Acta. 2005. PMID: 15615635 Free article. Review.

6

Sites of tau important for aggregation populate {beta}-structure and bind to microtubules and polyanions.

Mukrasch MD, Biernat J, von Bergen M, Griesinger C, Mandelkow E, Zweckstetter M. Mukrasch MD, et al. Among authors: mandelkow e. J Biol Chem. 2005 Jul 1;280(26):24978-86. doi: 10.1074/jbc.M501565200. Epub 2005 Apr 26. J Biol Chem. 2005. PMID: 15855160 Free article.

7

Screening for inhibitors of tau polymerization.

Pickhardt M, von Bergen M, Gazova Z, Hascher A, Biernat J, Mandelkow EM, Mandelkow E. Pickhardt M, et al. Among authors: mandelkow em, mandelkow e. Curr Alzheimer Res. 2005 Apr;2(2):219-26. doi: 10.2174/1567205053585891. Curr Alzheimer Res. 2005. PMID: 15974921

8

Purification of recombinant tau protein and preparation of Alzheimer-paired helical filaments in vitro.

Barghorn S, Biernat J, Mandelkow E. Barghorn S, et al. Among authors: mandelkow e. Methods Mol Biol. 2005;299:35-51. doi: 10.1385/1-59259-874-9:035. Methods Mol Biol. 2005. PMID: 15980594

9

Intrinsic fluorescent detection of tau conformation and aggregation.

von Bergen M, Li L, Mandelkow E. von Bergen M, et al. Among authors: mandelkow e. Methods Mol Biol. 2005;299:175-84. doi: 10.1385/1-59259-874-9:175. Methods Mol Biol. 2005. PMID: 15980601

10

Inducible expression of Tau repeat domain in cell models of tauopathy: aggregation is toxic to cells but can be reversed by inhibitor drugs.

Khlistunova I, Biernat J, Wang Y, Pickhardt M, von Bergen M, Gazova Z, Mandelkow E, Mandelkow EM. Khlistunova I, et al. Among authors: mandelkow em, mandelkow e. J Biol Chem. 2006 Jan 13;281(2):1205-14. doi: 10.1074/jbc.M507753200. Epub 2005 Oct 24. J Biol Chem. 2006. PMID: 16246844 Free article.

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