Upadhyay AK - Search Results

1

The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity.

Bromberg KD, Mitchell TR, Upadhyay AK, Jakob CG, Jhala MA, Comess KM, Lasko LM, Li C, Tuzon CT, Dai Y, Li F, Eram MS, Nuber A, Soni NB, Manaves V, Algire MA, Sweis RF, Torrent M, Schotta G, Sun C, Michaelides MR, Shoemaker AR, Arrowsmith CH, Brown PJ, Santhakumar V, Martin A, Rice JC, Chiang GG, Vedadi M, Barsyte-Lovejoy D, Pappano WN. Bromberg KD, et al. Among authors: upadhyay ak. Nat Chem Biol. 2017 Mar;13(3):317-324. doi: 10.1038/nchembio.2282. Epub 2017 Jan 23. Nat Chem Biol. 2017. PMID: 28114273

2

Turning a Substrate Peptide into a Potent Inhibitor for the Histone Methyltransferase SETD8.

Judge RA, Zhu H, Upadhyay AK, Bodelle PM, Hutchins CW, Torrent M, Marin VL, Yu W, Vedadi M, Li F, Brown PJ, Pappano WN, Sun C, Petros AM. Judge RA, et al. Among authors: upadhyay ak. ACS Med Chem Lett. 2016 Oct 11;7(12):1102-1106. doi: 10.1021/acsmedchemlett.6b00303. eCollection 2016 Dec 8. ACS Med Chem Lett. 2016. PMID: 27994746 Free PMC article.

3

Crystal structure of full-length Zika virus NS5 protein reveals a conformation similar to Japanese encephalitis virus NS5.

Upadhyay AK, Cyr M, Longenecker K, Tripathi R, Sun C, Kempf DJ. Upadhyay AK, et al. Acta Crystallogr F Struct Biol Commun. 2017 Mar 1;73(Pt 3):116-122. doi: 10.1107/S2053230X17001601. Epub 2017 Feb 21. Acta Crystallogr F Struct Biol Commun. 2017. PMID: 28291746 Free PMC article.

4

Novel Modes of Inhibition of Wild-Type Isocitrate Dehydrogenase 1 (IDH1): Direct Covalent Modification of His315.

Jakob CG, Upadhyay AK, Donner PL, Nicholl E, Addo SN, Qiu W, Ling C, Gopalakrishnan SM, Torrent M, Cepa SP, Shanley J, Shoemaker AR, Sun CC, Vasudevan A, Woller KR, Shotwell JB, Shaw B, Bian Z, Hutti JE. Jakob CG, et al. Among authors: upadhyay ak. J Med Chem. 2018 Aug 9;61(15):6647-6657. doi: 10.1021/acs.jmedchem.8b00305. Epub 2018 Jul 30. J Med Chem. 2018. PMID: 30004704

5

Targeting lysine specific demethylase 4A (KDM4A) tandem TUDOR domain - A fragment based approach.

Upadhyay AK, Judge RA, Li L, Pithawalla R, Simanis J, Bodelle PM, Marin VL, Henry RF, Petros AM, Sun C. Upadhyay AK, et al. Bioorg Med Chem Lett. 2018 Jun 1;28(10):1708-1713. doi: 10.1016/j.bmcl.2018.04.050. Epub 2018 Apr 19. Bioorg Med Chem Lett. 2018. PMID: 29691138

6

NMR-based fragment screening and lead discovery accelerated by principal component analysis.

Namanja AT, Xu J, Wu H, Sun Q, Upadhyay AK, Sun C, Van Doren SR, Petros AM. Namanja AT, et al. Among authors: upadhyay ak. J Biomol NMR. 2019 Dec;73(12):675-685. doi: 10.1007/s10858-019-00279-9. Epub 2019 Sep 20. J Biomol NMR. 2019. PMID: 31541395

7

Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294.

Chang Y, Zhang X, Horton JR, Upadhyay AK, Spannhoff A, Liu J, Snyder JP, Bedford MT, Cheng X. Chang Y, et al. Among authors: upadhyay ak. Nat Struct Mol Biol. 2009 Mar;16(3):312-7. doi: 10.1038/nsmb.1560. Epub 2009 Feb 15. Nat Struct Mol Biol. 2009. PMID: 19219047 Free PMC article.

8

An analog of BIX-01294 selectively inhibits a family of histone H3 lysine 9 Jumonji demethylases.

Upadhyay AK, Rotili D, Han JW, Hu R, Chang Y, Labella D, Zhang X, Yoon YS, Mai A, Cheng X. Upadhyay AK, et al. J Mol Biol. 2012 Feb 24;416(3):319-27. doi: 10.1016/j.jmb.2011.12.036. Epub 2011 Dec 29. J Mol Biol. 2012. PMID: 22227394 Free PMC article.

9

The Role of N-α-acetyltransferase 10 Protein in DNA Methylation and Genomic Imprinting.

Lee CC, Peng SH, Shen L, Lee CF, Du TH, Kang ML, Xu GL, Upadhyay AK, Cheng X, Yan YT, Zhang Y, Juan LJ. Lee CC, et al. Among authors: upadhyay ak. Mol Cell. 2017 Oct 5;68(1):89-103.e7. doi: 10.1016/j.molcel.2017.08.025. Epub 2017 Sep 21. Mol Cell. 2017. PMID: 28943313 Free PMC article.

10

A methylation and phosphorylation switch between an adjacent lysine and serine determines human DNMT1 stability.

Estève PO, Chang Y, Samaranayake M, Upadhyay AK, Horton JR, Feehery GR, Cheng X, Pradhan S. Estève PO, et al. Among authors: upadhyay ak. Nat Struct Mol Biol. 2011 Jan;18(1):42-8. doi: 10.1038/nsmb.1939. Epub 2010 Dec 12. Nat Struct Mol Biol. 2011. PMID: 21151116 Free PMC article.

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