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Sigma-2 receptor agonist derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) induce cell death via mitochondrial superoxide production and caspase activation in pancreatic cancer.
Pati ML, Hornick JR, Niso M, Berardi F, Spitzer D, Abate C, Hawkins W. Pati ML, et al. Among authors: hornick jr. BMC Cancer. 2017 Jan 13;17(1):51. doi: 10.1186/s12885-016-3040-4. BMC Cancer. 2017. PMID: 28086830 Free PMC article.
Fluorescent derivatives of σ receptor ligand 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) as a tool for uptake and cellular localization studies in pancreatic tumor cells.
Abate C, Hornick JR, Spitzer D, Hawkins WG, Niso M, Perrone R, Berardi F. Abate C, et al. Among authors: hornick jr. J Med Chem. 2011 Aug 25;54(16):5858-67. doi: 10.1021/jm200591t. Epub 2011 Jul 20. J Med Chem. 2011. PMID: 21744858 Free PMC article.
A phase I study of IMP321 and gemcitabine as the front-line therapy in patients with advanced pancreatic adenocarcinoma.
Wang-Gillam A, Plambeck-Suess S, Goedegebuure P, Simon PO, Mitchem JB, Hornick JR, Sorscher S, Picus J, Suresh R, Lockhart AC, Tan B, Hawkins WG. Wang-Gillam A, et al. Among authors: hornick jr. Invest New Drugs. 2013 Jun;31(3):707-13. doi: 10.1007/s10637-012-9866-y. Epub 2012 Aug 4. Invest New Drugs. 2013. PMID: 22864469 Free PMC article. Clinical Trial.
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