Macor JE - Search Results

1

Design and Synthesis of a New Series of 4-Heteroarylamino-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octanes as α7 Nicotinic Receptor Agonists. 1. Development of Pharmacophore and Early Structure-Activity Relationship.

Cook J, Zusi FC, McDonald IM, King D, Hill MD, Iwuagwu C, Mate RA, Fang H, Zhao R, Wang B, Cutrone J, Ma B, Gao Q, Knox RJ, Matchett M, Gallagher L, Ferrante M, Post-Munson D, Molski T, Easton A, Miller R, Jones K, Digavalli S, Healy F, Lentz K, Benitex Y, Clarke W, Natale J, Siuciak JA, Lodge N, Zaczek R, Denton R, Morgan D, Bristow LJ, Macor JE, Olson RE. Cook J, et al. Among authors: macor je. J Med Chem. 2016 Dec 22;59(24):11171-11181. doi: 10.1021/acs.jmedchem.6b01506. Epub 2016 Dec 13. J Med Chem. 2016. PMID: 27958732

2

1-(2-Aminoethyl)-3-methyl-8,9-dihydropyrano[3,2-e]indole: a rotationally restricted phenolic analog of the neurotransmitter serotonin and agonist selective for serotonin (5-HT2-type) receptors.

Macor JE, Fox CB, Johnson C, Koe BK, Lebel LA, Zorn SH. Macor JE, et al. J Med Chem. 1992 Oct 2;35(20):3625-32. doi: 10.1021/jm00098a005. J Med Chem. 1992. PMID: 1433172

3

Synthesis and serotonergic pharmacology of the enantiomers of 3-[(N-methylpyrrolidin-2-yl)methyl]-5-methoxy-1H-indole: discovery of stereogenic differentiation in the aminoethyl side chain of the neurotransmitter serotonin.

Macor JE, Blake J, Fox CB, Johnson C, Koe BK, Lebel LA, Morrone JM, Ryan K, Schmidt AW, Schulz DW, et al. Macor JE, et al. J Med Chem. 1992 Nov 13;35(23):4503-5. doi: 10.1021/jm00101a032. J Med Chem. 1992. PMID: 1447752 No abstract available.

4

3-(1,2,5,6-Tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyrid-5-one: a potent and selective serotonin (5-HT1B) agonist and rotationally restricted phenolic analogue of 5-methoxy-3-(1,2,5,6-tetrahydropyrid-4-yl)indole.

Macor JE, Burkhart CA, Heym JH, Ives JL, Lebel LA, Newman ME, Nielsen JA, Ryan K, Schulz DW, Torgersen LK, et al. Macor JE, et al. J Med Chem. 1990 Aug;33(8):2087-93. doi: 10.1021/jm00170a007. J Med Chem. 1990. PMID: 2374139

5

5-[(3-nitropyrid-2-yl)amino]indoles: novel serotonin agonists with selectivity for the 5-HT1D receptor. Variation of the C3 substituent on the indole template leads to increased 5-HT1D receptor selectivity.

Macor JE, Blank DH, Fox CB, Lebel LA, Newman ME, Post RJ, Ryan K, Schmidt AW, Schulz DW, Koe BK. Macor JE, et al. J Med Chem. 1994 Aug 5;37(16):2509-12. doi: 10.1021/jm00042a003. J Med Chem. 1994. PMID: 8057297 No abstract available.

6

N-3-substituted imidazoquinazolinones: potent and selective PDE5 inhibitors as potential agents for treatment of erectile dysfunction.

Rotella DP, Sun Z, Zhu Y, Krupinski J, Pongrac R, Seliger L, Normandin D, Macor JE. Rotella DP, et al. Among authors: macor je. J Med Chem. 2000 Apr 6;43(7):1257-63. doi: 10.1021/jm000081+. J Med Chem. 2000. PMID: 10753463

7

(-)-Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidin-2'-one], a conformationally restricted analogue of acetylcholine, is a highly selective full agonist at the alpha 7 nicotinic acetylcholine receptor.

Mullen G, Napier J, Balestra M, DeCory T, Hale G, Macor J, Mack R, Loch J 3rd, Wu E, Kover A, Verhoest P, Sampognaro A, Phillips E, Zhu Y, Murray R, Griffith R, Blosser J, Gurley D, Machulskis A, Zongrone J, Rosen A, Gordon J. Mullen G, et al. J Med Chem. 2000 Nov 2;43(22):4045-50. doi: 10.1021/jm000249r. J Med Chem. 2000. PMID: 11063601

8

Optimization of substituted N-3-benzylimidazoquinazolinone sulfonamides as potent and selective PDE5 inhibitors.

Rotella DP, Sun Z, Zhu Y, Krupinski J, Pongrac R, Seliger L, Normandin D, Macor JE. Rotella DP, et al. Among authors: macor je. J Med Chem. 2000 Dec 28;43(26):5037-43. doi: 10.1021/jm000336j. J Med Chem. 2000. PMID: 11150175

9

The 5-HT3 antagonist tropisetron (ICS 205-930) is a potent and selective alpha7 nicotinic receptor partial agonist.

Macor JE, Gurley D, Lanthorn T, Loch J, Mack RA, Mullen G, Tran O, Wright N, Gordon JC. Macor JE, et al. Bioorg Med Chem Lett. 2001 Feb 12;11(3):319-21. doi: 10.1016/s0960-894x(00)00670-3. Bioorg Med Chem Lett. 2001. PMID: 11212100

10

Substituted pyrazolopyridines as potent and selective PDE5 inhibitors: potential agents for treatment of erectile dysfunction.

Yu G, Mason HJ, Wu X, Wang J, Chong S, Dorough G, Henwood A, Pongrac R, Seliger L, He B, Normandin D, Adam L, Krupinski J, Macor JE. Yu G, et al. Among authors: macor je. J Med Chem. 2001 Mar 29;44(7):1025-7. doi: 10.1021/jm0155042. J Med Chem. 2001. PMID: 11297448 No abstract available.

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