Gestwicki JE - Search Results

1

BAG3 Is a Modular, Scaffolding Protein that physically Links Heat Shock Protein 70 (Hsp70) to the Small Heat Shock Proteins.

Rauch JN, Tse E, Freilich R, Mok SA, Makley LN, Southworth DR, Gestwicki JE. Rauch JN, et al. Among authors: gestwicki je. J Mol Biol. 2017 Jan 6;429(1):128-141. doi: 10.1016/j.jmb.2016.11.013. Epub 2016 Nov 21. J Mol Biol. 2017. PMID: 27884606 Free PMC article.

2

Heat shock proteins 70 and 90 inhibit early stages of amyloid beta-(1-42) aggregation in vitro.

Evans CG, Wisén S, Gestwicki JE. Evans CG, et al. Among authors: gestwicki je. J Biol Chem. 2006 Nov 3;281(44):33182-91. doi: 10.1074/jbc.M606192200. Epub 2006 Sep 14. J Biol Chem. 2006. PMID: 16973602 Free article.

3

Chemical modulators of heat shock protein 70 (Hsp70) by sequential, microwave-accelerated reactions on solid phase.

Wisén S, Androsavich J, Evans CG, Chang L, Gestwicki JE. Wisén S, et al. Among authors: gestwicki je. Bioorg Med Chem Lett. 2008 Jan 1;18(1):60-5. doi: 10.1016/j.bmcl.2007.11.027. Epub 2007 Nov 17. Bioorg Med Chem Lett. 2008. PMID: 18060774

4

Identification of small molecules that modify the protein folding activity of heat shock protein 70.

Wisén S, Gestwicki JE. Wisén S, et al. Among authors: gestwicki je. Anal Biochem. 2008 Mar 15;374(2):371-7. doi: 10.1016/j.ab.2007.12.009. Epub 2007 Dec 14. Anal Biochem. 2008. PMID: 18191466

5

Solution conformation of wild-type E. coli Hsp70 (DnaK) chaperone complexed with ADP and substrate.

Bertelsen EB, Chang L, Gestwicki JE, Zuiderweg ER. Bertelsen EB, et al. Among authors: gestwicki je. Proc Natl Acad Sci U S A. 2009 May 26;106(21):8471-6. doi: 10.1073/pnas.0903503106. Epub 2009 May 13. Proc Natl Acad Sci U S A. 2009. PMID: 19439666 Free PMC article.

6

Pharmacological targeting of the Hsp70 chaperone.

Patury S, Miyata Y, Gestwicki JE. Patury S, et al. Among authors: gestwicki je. Curr Top Med Chem. 2009;9(15):1337-51. doi: 10.2174/156802609789895674. Curr Top Med Chem. 2009. PMID: 19860737 Free PMC article. Review.

7

Heat shock protein 70 (hsp70) as an emerging drug target.

Evans CG, Chang L, Gestwicki JE. Evans CG, et al. Among authors: gestwicki je. J Med Chem. 2010 Jun 24;53(12):4585-602. doi: 10.1021/jm100054f. J Med Chem. 2010. PMID: 20334364 Free PMC article. Review. No abstract available.

8

Mutagenesis reveals the complex relationships between ATPase rate and the chaperone activities of Escherichia coli heat shock protein 70 (Hsp70/DnaK).

Chang L, Thompson AD, Ung P, Carlson HA, Gestwicki JE. Chang L, et al. Among authors: gestwicki je. J Biol Chem. 2010 Jul 9;285(28):21282-91. doi: 10.1074/jbc.M110.124149. Epub 2010 May 3. J Biol Chem. 2010. PMID: 20439464 Free PMC article.

9

Binding of a small molecule at a protein-protein interface regulates the chaperone activity of hsp70-hsp40.

Wisén S, Bertelsen EB, Thompson AD, Patury S, Ung P, Chang L, Evans CG, Walter GM, Wipf P, Carlson HA, Brodsky JL, Zuiderweg ER, Gestwicki JE. Wisén S, et al. Among authors: gestwicki je. ACS Chem Biol. 2010 Jun 18;5(6):611-22. doi: 10.1021/cb1000422. ACS Chem Biol. 2010. PMID: 20481474 Free PMC article.

10

High-throughput screen for Escherichia coli heat shock protein 70 (Hsp70/DnaK): ATPase assay in low volume by exploiting energy transfer.

Miyata Y, Chang L, Bainor A, McQuade TJ, Walczak CP, Zhang Y, Larsen MJ, Kirchhoff P, Gestwicki JE. Miyata Y, et al. Among authors: gestwicki je. J Biomol Screen. 2010 Dec;15(10):1211-9. doi: 10.1177/1087057110380571. Epub 2010 Oct 6. J Biomol Screen. 2010. PMID: 20926844 Free PMC article.

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