The alarmin S100A9 hampers osteoclast differentiation from human circulating precursors by reducing the expression of RANK.
Di Ceglie I, Blom AB, Davar R, Logie C, Martens JHA, Habibi E, Böttcher LM, Roth J, Vogl T, Goodyear CS, van der Kraan PM, van Lent PL, van den Bosch MH.
Di Ceglie I, et al. Among authors: davar r.
FASEB J. 2019 Sep;33(9):10104-10115. doi: 10.1096/fj.201802691RR. Epub 2019 Jun 14.
FASEB J. 2019.
PMID: 31199668
Together, our data show that S100A9 impedes monocyte-to-osteoclast differentiation, probably via a reduction in RANK expression.-Di Ceglie, I., Blom, A. B., Davar, R., Logie, C., Martens, J. H. A., Habibi, E., Bottcher, L.-M., Roth, J., Vogl, T., Goodyear, C. ...
Together, our data show that S100A9 impedes monocyte-to-osteoclast differentiation, probably via a reduction in RANK expression.-Di Ceglie, …