de Araujo AD - Search Results

1

Helixconstraints and amino acid substitution in GLP-1 increase cAMP and insulin secretion but not beta-arrestin 2 signaling.

Plisson F, Hill TA, Mitchell JM, Hoang HN, de Araujo AD, Xu W, Cotterell A, Edmonds DJ, Stanton RV, Derksen DR, Loria PM, Griffith DA, Price DA, Liras S, Fairlie DP. Plisson F, et al. Among authors: de araujo ad. Eur J Med Chem. 2017 Feb 15;127:703-714. doi: 10.1016/j.ejmech.2016.10.044. Epub 2016 Oct 21. Eur J Med Chem. 2017. PMID: 27823886

2

Comparative α-helicity of cyclic pentapeptides in water.

de Araujo AD, Hoang HN, Kok WM, Diness F, Gupta P, Hill TA, Driver RW, Price DA, Liras S, Fairlie DP. de Araujo AD, et al. Angew Chem Int Ed Engl. 2014 Jul 1;53(27):6965-9. doi: 10.1002/anie.201310245. Epub 2014 May 14. Angew Chem Int Ed Engl. 2014. PMID: 24828311

3

Contiguous hydrophobic and charged surface patches in short helix-constrained peptides drive cell permeability.

Perry SR, Hill TA, de Araujo AD, Hoang HN, Fairlie DP. Perry SR, et al. Among authors: de araujo ad. Org Biomol Chem. 2018 Jan 17;16(3):367-371. doi: 10.1039/c7ob02952g. Org Biomol Chem. 2018. PMID: 29264603

4

Landscaping macrocyclic peptides: stapling hDM2-binding peptides for helicity, protein affinity, proteolytic stability and cell uptake.

de Araujo AD, Lim J, Wu KC, Hoang HN, Nguyen HT, Fairlie DP. de Araujo AD, et al. RSC Chem Biol. 2022 May 31;3(7):895-904. doi: 10.1039/d1cb00231g. eCollection 2022 Jul 6. RSC Chem Biol. 2022. PMID: 35866171 Free PMC article.

5

Late-Stage Hydrocarbon Conjugation and Cyclisation in Synthetic Peptides and Proteins.

de Araujo AD, Nguyen HT, Fairlie DP. de Araujo AD, et al. Chembiochem. 2021 May 14;22(10):1784-1789. doi: 10.1002/cbic.202000796. Epub 2021 Mar 15. Chembiochem. 2021. PMID: 33506598

6

Electrophilic Helical Peptides That Bond Covalently, Irreversibly, and Selectively in a Protein-Protein Interaction Site.

de Araujo AD, Lim J, Good AC, Skerlj RT, Fairlie DP. de Araujo AD, et al. ACS Med Chem Lett. 2016 Nov 15;8(1):22-26. doi: 10.1021/acsmedchemlett.6b00395. eCollection 2017 Jan 12. ACS Med Chem Lett. 2016. PMID: 28105269 Free PMC article.

7

Tuning Electrostatic and Hydrophobic Surfaces of Aromatic Rings to Enhance Membrane Association and Cell Uptake of Peptides.

de Araujo AD, Hoang HN, Lim J, Mak JYW, Fairlie DP. de Araujo AD, et al. Angew Chem Int Ed Engl. 2022 Jul 18;61(29):e202203995. doi: 10.1002/anie.202203995. Epub 2022 May 25. Angew Chem Int Ed Engl. 2022. PMID: 35523729 Free PMC article.

8

Development of cell-penetrating peptide-based drug leads to inhibit MDMX:p53 and MDM2:p53 interactions.

Philippe G, Huang YH, Cheneval O, Lawrence N, Zhang Z, Fairlie DP, Craik DJ, de Araujo AD, Henriques ST. Philippe G, et al. Among authors: de araujo ad. Biopolymers. 2016 Nov;106(6):853-863. doi: 10.1002/bip.22893. Biopolymers. 2016. PMID: 27287767

9

Taking the Myc out of cancer: toward therapeutic strategies to directly inhibit c-Myc.

Madden SK, de Araujo AD, Gerhardt M, Fairlie DP, Mason JM. Madden SK, et al. Among authors: de araujo ad. Mol Cancer. 2021 Jan 4;20(1):3. doi: 10.1186/s12943-020-01291-6. Mol Cancer. 2021. PMID: 33397405 Free PMC article. Review.

10

Fortified Coiled Coils: Enhancing Mechanical Stability with Lactam or Metal Staples.

López-García P, de Araujo AD, Bergues-Pupo AE, Tunn I, Fairlie DP, Blank KG. López-García P, et al. Among authors: de araujo ad. Angew Chem Int Ed Engl. 2021 Jan 4;60(1):232-236. doi: 10.1002/anie.202006971. Epub 2020 Oct 29. Angew Chem Int Ed Engl. 2021. PMID: 32940968 Free PMC article.

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