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Helixconstraints and amino acid substitution in GLP-1 increase cAMP and insulin secretion but not beta-arrestin 2 signaling.
Plisson F, Hill TA, Mitchell JM, Hoang HN, de Araujo AD, Xu W, Cotterell A, Edmonds DJ, Stanton RV, Derksen DR, Loria PM, Griffith DA, Price DA, Liras S, Fairlie DP. Plisson F, et al. Among authors: cotterell a. Eur J Med Chem. 2017 Feb 15;127:703-714. doi: 10.1016/j.ejmech.2016.10.044. Epub 2016 Oct 21. Eur J Med Chem. 2017. PMID: 27823886
PAR2 Modulators Derived from GB88.
Yau MK, Liu L, Suen JY, Lim J, Lohman RJ, Jiang Y, Cotterell AJ, Barry GD, Mak JY, Vesey DA, Reid RC, Fairlie DP. Yau MK, et al. Among authors: cotterell aj. ACS Med Chem Lett. 2016 Oct 10;7(12):1179-1184. doi: 10.1021/acsmedchemlett.6b00306. eCollection 2016 Dec 8. ACS Med Chem Lett. 2016. PMID: 27994760 Free PMC article.
Pathway-selective antagonism of proteinase activated receptor 2.
Suen JY, Cotterell A, Lohman RJ, Lim J, Han A, Yau MK, Liu L, Cooper MA, Vesey DA, Fairlie DP. Suen JY, et al. Among authors: cotterell a. Br J Pharmacol. 2014 Sep;171(17):4112-24. doi: 10.1111/bph.12757. Epub 2014 Jul 2. Br J Pharmacol. 2014. PMID: 24821440 Free PMC article.
91 results