Liver p53 is stabilized upon starvation and required for amino acid catabolism and gluconeogenesis.
Prokesch A, Graef FA, Madl T, Kahlhofer J, Heidenreich S, Schumann A, Moyschewitz E, Pristoynik P, Blaschitz A, Knauer M, Muenzner M, Bogner-Strauss JG, Dohr G, Schulz TJ, Schupp M.
Prokesch A, et al.
FASEB J. 2017 Feb;31(2):732-742. doi: 10.1096/fj.201600845R. Epub 2016 Nov 3.
FASEB J. 2017.
PMID: 27811061
Free PMC article.
Here we report a previously unrecognized role of the tumor suppressor p53 in the physiologic adaptation to food withdrawal. ...Because of its tumor suppressor function, p53 stabilization by starvation could have implications for both metabolic and oncological diseases of t …
Here we report a previously unrecognized role of the tumor suppressor p53 in the physiologic adaptation to food withdrawal. ...Becaus …