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Page 1
Liver p53 is stabilized upon starvation and required for amino acid catabolism and gluconeogenesis.
Prokesch A, Graef FA, Madl T, Kahlhofer J, Heidenreich S, Schumann A, Moyschewitz E, Pristoynik P, Blaschitz A, Knauer M, Muenzner M, Bogner-Strauss JG, Dohr G, Schulz TJ, Schupp M. Prokesch A, et al. Among authors: madl t. FASEB J. 2017 Feb;31(2):732-742. doi: 10.1096/fj.201600845R. Epub 2016 Nov 3. FASEB J. 2017. PMID: 27811061 Free PMC article.
Because of its tumor suppressor function, p53 stabilization by starvation could have implications for both metabolic and oncological diseases of the liver.-Prokesch, A., Graef, F. A., Madl, T., Kahlhofer, J., Heidenreich, S., Schumann, A., Moyschewitz, E., Pristoyni …
Because of its tumor suppressor function, p53 stabilization by starvation could have implications for both metabolic and oncological disease …
Cytosolic Aspartate Availability Determines Cell Survival When Glutamine Is Limiting.
Alkan HF, Walter KE, Luengo A, Madreiter-Sokolowski CT, Stryeck S, Lau AN, Al-Zoughbi W, Lewis CA, Thomas CJ, Hoefler G, Graier WF, Madl T, Vander Heiden MG, Bogner-Strauss JG. Alkan HF, et al. Among authors: madl t. Cell Metab. 2018 Nov 6;28(5):706-720.e6. doi: 10.1016/j.cmet.2018.07.021. Epub 2018 Aug 16. Cell Metab. 2018. PMID: 30122555 Free PMC article.
N-acetylaspartate pathway is nutrient responsive and coordinates lipid and energy metabolism in brown adipocytes.
Huber K, Hofer DC, Trefely S, Pelzmann HJ, Madreiter-Sokolowski C, Duta-Mare M, Schlager S, Trausinger G, Stryeck S, Graier WF, Kolb D, Magnes C, Snyder NW, Prokesch A, Kratky D, Madl T, Wellen KE, Bogner-Strauss JG. Huber K, et al. Among authors: madl t. Biochim Biophys Acta Mol Cell Res. 2019 Mar;1866(3):337-348. doi: 10.1016/j.bbamcr.2018.08.017. Epub 2018 Aug 31. Biochim Biophys Acta Mol Cell Res. 2019. PMID: 30595160 Free PMC article.
Fasting improves therapeutic response in hepatocellular carcinoma through p53-dependent metabolic synergism.
Krstic J, Reinisch I, Schindlmaier K, Galhuber M, Riahi Z, Berger N, Kupper N, Moyschewitz E, Auer M, Michenthaler H, Nössing C, Depaoli MR, Ramadani-Muja J, Usluer S, Stryeck S, Pichler M, Rinner B, Deutsch AJA, Reinisch A, Madl T, Chiozzi RZ, Heck AJR, Huch M, Malli R, Prokesch A. Krstic J, et al. Among authors: madl t. Sci Adv. 2022 Jan 21;8(3):eabh2635. doi: 10.1126/sciadv.abh2635. Epub 2022 Jan 21. Sci Adv. 2022. PMID: 35061544 Free PMC article.
Complementary omics strategies to dissect p53 signaling networks under nutrient stress.
Galhuber M, Michenthaler H, Heininger C, Reinisch I, Nössing C, Krstic J, Kupper N, Moyschewitz E, Auer M, Heitzer E, Ulz P, Birner-Gruenberger R, Liesinger L, Lenihan-Geels GN, Oster M, Spreitzer E, Zenezini Chiozzi R, Schulz TJ, Schupp M, Madl T, Heck AJR, Prokesch A. Galhuber M, et al. Among authors: madl t. Cell Mol Life Sci. 2022 May 30;79(6):326. doi: 10.1007/s00018-022-04345-8. Cell Mol Life Sci. 2022. PMID: 35635656 Free PMC article.
p53 Regulates a miRNA-Fructose Transporter Axis in Brown Adipose Tissue Under Fasting.
Reinisch I, Klymiuk I, Michenthaler H, Moyschewitz E, Galhuber M, Krstic J, Domingo M, Zhang F, Karbiener M, Vujić N, Kratky D, Schreiber R, Schupp M, Lenihan-Geels G, Schulz TJ, Malli R, Madl T, Prokesch A. Reinisch I, et al. Among authors: madl t. Front Genet. 2022 Jun 6;13:913030. doi: 10.3389/fgene.2022.913030. eCollection 2022. Front Genet. 2022. PMID: 35734423 Free PMC article.
Hepatic p53 is regulated by transcription factor FOXO1 and acutely controls glycogen homeostasis.
Oster M, Galhuber M, Krstic J, Steinhoff JS, Lenihan-Geels G, Wulff S, Kiefer MF, Petricek KM, Wowro SJ, Flores RE, Yang N, Li C, Meng Y, Reinisch I, Sommerfeld M, Weger S, Habisch H, Madl T, Schulz TJ, Prokesch A, Schupp M. Oster M, et al. Among authors: madl t. J Biol Chem. 2022 Sep;298(9):102287. doi: 10.1016/j.jbc.2022.102287. Epub 2022 Jul 20. J Biol Chem. 2022. PMID: 35868560 Free PMC article.
Disordered regions mediate the interaction of p53 and MRE11.
Usluer S, Galhuber M, Khanna Y, Bourgeois B, Spreitzer E, Michenthaler H, Prokesch A, Madl T. Usluer S, et al. Among authors: madl t. Biochim Biophys Acta Mol Cell Res. 2024 Feb;1871(2):119654. doi: 10.1016/j.bbamcr.2023.119654. Epub 2023 Dec 19. Biochim Biophys Acta Mol Cell Res. 2024. PMID: 38123020 Free article.
Regulation of cellular senescence via the FOXO4-p53 axis.
Bourgeois B, Madl T. Bourgeois B, et al. Among authors: madl t. FEBS Lett. 2018 Jun;592(12):2083-2097. doi: 10.1002/1873-3468.13057. Epub 2018 May 25. FEBS Lett. 2018. PMID: 29683489 Free PMC article. Review.
Lysosomal acid lipase regulates VLDL synthesis and insulin sensitivity in mice.
Radović B, Vujić N, Leopold C, Schlager S, Goeritzer M, Patankar JV, Korbelius M, Kolb D, Reindl J, Wegscheider M, Tomin T, Birner-Gruenberger R, Schittmayer M, Groschner L, Magnes C, Diwoky C, Frank S, Steyrer E, Du H, Graier WF, Madl T, Kratky D. Radović B, et al. Among authors: madl t. Diabetologia. 2016 Aug;59(8):1743-52. doi: 10.1007/s00125-016-3968-6. Epub 2016 May 6. Diabetologia. 2016. PMID: 27153842 Free PMC article.
190 results