O'Donoghue AJ - Search Results

1

Design of Selective Substrates and Activity-Based Probes for Hydrolase Important for Pathogenesis 1 (HIP1) from Mycobacterium tuberculosis.

Lentz CS, Ordonez AA, Kasperkiewicz P, La Greca F, O'Donoghue AJ, Schulze CJ, Powers JC, Craik CS, Drag M, Jain SK, Bogyo M. Lentz CS, et al. ACS Infect Dis. 2016 Nov 11;2(11):807-815. doi: 10.1021/acsinfecdis.6b00092. Epub 2016 Jul 15. ACS Infect Dis. 2016. PMID: 27739665 Free PMC article.

2

Inhibition of a secreted glutamic peptidase prevents growth of the fungus Talaromyces emersonii.

O'Donoghue AJ, Mahon CS, Goetz DH, O'Malley JM, Gallagher DM, Zhou M, Murray PG, Craik CS, Tuohy MG. O'Donoghue AJ, et al. J Biol Chem. 2008 Oct 24;283(43):29186-95. doi: 10.1074/jbc.M802366200. Epub 2008 Aug 7. J Biol Chem. 2008. PMID: 18687686 Free PMC article.

3

A parasite cysteine protease is key to host protein degradation and iron acquisition.

O'Brien TC, Mackey ZB, Fetter RD, Choe Y, O'Donoghue AJ, Zhou M, Craik CS, Caffrey CR, McKerrow JH. O'Brien TC, et al. J Biol Chem. 2008 Oct 24;283(43):28934-43. doi: 10.1074/jbc.M805824200. Epub 2008 Aug 13. J Biol Chem. 2008. PMID: 18701454 Free PMC article.

4

Characterization of a multimeric, eukaryotic prolyl aminopeptidase: an inducible and highly specific intracellular peptidase from the non-pathogenic fungus Talaromyces emersonii.

Mahon CS, O'Donoghue AJ, Goetz DH, Murray PG, Craik CS, Tuohy MG. Mahon CS, et al. Microbiology (Reading). 2009 Nov;155(Pt 11):3673-3682. doi: 10.1099/mic.0.030940-0. Epub 2009 Jun 25. Microbiology (Reading). 2009. PMID: 19556294 Free PMC article.

5

Global landscape of HIV-human protein complexes.

Jäger S, Cimermancic P, Gulbahce N, Johnson JR, McGovern KE, Clarke SC, Shales M, Mercenne G, Pache L, Li K, Hernandez H, Jang GM, Roth SL, Akiva E, Marlett J, Stephens M, D'Orso I, Fernandes J, Fahey M, Mahon C, O'Donoghue AJ, Todorovic A, Morris JH, Maltby DA, Alber T, Cagney G, Bushman FD, Young JA, Chanda SK, Sundquist WI, Kortemme T, Hernandez RD, Craik CS, Burlingame A, Sali A, Frankel AD, Krogan NJ. Jäger S, et al. Nature. 2011 Dec 21;481(7381):365-70. doi: 10.1038/nature10719. Nature. 2011. PMID: 22190034 Free PMC article.

6

Global identification of peptidase specificity by multiplex substrate profiling.

O'Donoghue AJ, Eroy-Reveles AA, Knudsen GM, Ingram J, Zhou M, Statnekov JB, Greninger AL, Hostetter DR, Qu G, Maltby DA, Anderson MO, Derisi JL, McKerrow JH, Burlingame AL, Craik CS. O'Donoghue AJ, et al. Nat Methods. 2012 Nov;9(11):1095-100. doi: 10.1038/nmeth.2182. Epub 2012 Sep 30. Nat Methods. 2012. PMID: 23023596 Free PMC article.

7

Substrate specificity of MarP, a periplasmic protease required for resistance to acid and oxidative stress in Mycobacterium tuberculosis.

Small JL, O'Donoghue AJ, Boritsch EC, Tsodikov OV, Knudsen GM, Vandal O, Craik CS, Ehrt S. Small JL, et al. J Biol Chem. 2013 May 3;288(18):12489-99. doi: 10.1074/jbc.M113.456541. Epub 2013 Mar 15. J Biol Chem. 2013. PMID: 23504313 Free PMC article.

8

Dissecting the active site of the collagenolytic cathepsin L3 protease of the invasive stage of Fasciola hepatica.

Corvo I, O'Donoghue AJ, Pastro L, Pi-Denis N, Eroy-Reveles A, Roche L, McKerrow JH, Dalton JP, Craik CS, Caffrey CR, Tort JF. Corvo I, et al. PLoS Negl Trop Dis. 2013 Jul 11;7(7):e2269. doi: 10.1371/journal.pntd.0002269. Print 2013. PLoS Negl Trop Dis. 2013. PMID: 23875031 Free PMC article.

9

Global substrate profiling of proteases in human neutrophil extracellular traps reveals consensus motif predominantly contributed by elastase.

O'Donoghue AJ, Jin Y, Knudsen GM, Perera NC, Jenne DE, Murphy JE, Craik CS, Hermiston TW. O'Donoghue AJ, et al. PLoS One. 2013 Sep 20;8(9):e75141. doi: 10.1371/journal.pone.0075141. eCollection 2013. PLoS One. 2013. PMID: 24073241 Free PMC article.

10

Structural requirements for the collagenase and elastase activity of cathepsin K and its selective inhibition by an exosite inhibitor.

Sharma V, Panwar P, O'Donoghue AJ, Cui H, Guido RV, Craik CS, Brömme D. Sharma V, et al. Biochem J. 2015 Jan 1;465(1):163-73. doi: 10.1042/BJ20140809. Biochem J. 2015. PMID: 25279554

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