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Vasopressin lowers renal epoxyeicosatrienoic acid levels by activating soluble epoxide hydrolase.
Boldt C, Röschel T, Himmerkus N, Plain A, Bleich M, Labes R, Blum M, Krause H, Magheli A, Giesecke T, Mutig K, Rothe M, Weldon SM, Dragun D, Schunck WH, Bachmann S, Paliege A. Boldt C, et al. Among authors: schunck wh. Am J Physiol Renal Physiol. 2016 Dec 1;311(6):F1198-F1210. doi: 10.1152/ajprenal.00062.2016. Epub 2016 Sep 28. Am J Physiol Renal Physiol. 2016. PMID: 27681558 Free article.
Renal Ischemia/Reperfusion Injury in Soluble Epoxide Hydrolase-Deficient Mice.
Zhu Y, Blum M, Hoff U, Wesser T, Fechner M, Westphal C, Gürgen D, Catar RA, Philippe A, Wu K, Bubalo G, Rothe M, Weldon SM, Dragun D, Schunck WH. Zhu Y, et al. Among authors: schunck wh. PLoS One. 2016 Jan 4;11(1):e0145645. doi: 10.1371/journal.pone.0145645. eCollection 2016. PLoS One. 2016. PMID: 26727266 Free PMC article.
A synthetic epoxyeicosatrienoic acid analogue prevents the initiation of ischemic acute kidney injury.
Hoff U, Bubalo G, Fechner M, Blum M, Zhu Y, Pohlmann A, Hentschel J, Arakelyan K, Seeliger E, Flemming B, Gürgen D, Rothe M, Niendorf T, Manthati VL, Falck JR, Haase M, Schunck WH, Dragun D. Hoff U, et al. Among authors: schunck wh. Acta Physiol (Oxf). 2019 Oct;227(2):e13297. doi: 10.1111/apha.13297. Epub 2019 Jun 2. Acta Physiol (Oxf). 2019. PMID: 31077555 Free PMC article.
Soluble epoxide hydrolase is a susceptibility factor for heart failure in a rat model of human disease.
Monti J, Fischer J, Paskas S, Heinig M, Schulz H, Gösele C, Heuser A, Fischer R, Schmidt C, Schirdewan A, Gross V, Hummel O, Maatz H, Patone G, Saar K, Vingron M, Weldon SM, Lindpaintner K, Hammock BD, Rohde K, Dietz R, Cook SA, Schunck WH, Luft FC, Hubner N. Monti J, et al. Among authors: schunck wh. Nat Genet. 2008 May;40(5):529-37. doi: 10.1038/ng.129. Nat Genet. 2008. PMID: 18443590 Free PMC article.
Regulation of the cytochrome P450 epoxyeicosanoid pathway is associated with distinct histologic features in pediatric non-alcoholic fatty liver disease.
Kalveram L, Schunck WH, Rothe M, Rudolph B, Loddenkemper C, Holzhütter HG, Henning S, Bufler P, Schulz M, Meierhofer D, Zhang IW, Weylandt KH, Wiegand S, Hudert CA. Kalveram L, et al. Among authors: schunck wh. Prostaglandins Leukot Essent Fatty Acids. 2021 Jan;164:102229. doi: 10.1016/j.plefa.2020.102229. Epub 2020 Dec 17. Prostaglandins Leukot Essent Fatty Acids. 2021. PMID: 33388475 Clinical Trial.
124 results