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Page 1
Characterization of the molecular mechanism of 5-lipoxygenase inhibition by 2-aminothiazoles.
Kretschmer SB, Woltersdorf S, Vogt D, Lillich FF, Rühl M, Karas M, Maucher IV, Roos J, Häfner AK, Kaiser A, Wurglics M, Schubert-Zsilavecz M, Angioni C, Geisslinger G, Stark H, Steinhilber D, Hofmann B. Kretschmer SB, et al. Among authors: hafner ak. Biochem Pharmacol. 2017 Jan 1;123:52-62. doi: 10.1016/j.bcp.2016.09.021. Epub 2016 Sep 23. Biochem Pharmacol. 2017. PMID: 27671344
Sulindac sulfide suppresses 5-lipoxygenase at clinically relevant concentrations.
Steinbrink SD, Pergola C, Bühring U, George S, Metzner J, Fischer AS, Häfner AK, Wisniewska JM, Geisslinger G, Werz O, Steinhilber D, Maier TJ. Steinbrink SD, et al. Among authors: hafner ak. Cell Mol Life Sci. 2010 Mar;67(5):797-806. doi: 10.1007/s00018-009-0206-0. Epub 2009 Nov 29. Cell Mol Life Sci. 2010. PMID: 20091083 Free PMC article.
Dimerization of human 5-lipoxygenase.
Häfner AK, Cernescu M, Hofmann B, Ermisch M, Hörnig M, Metzner J, Schneider G, Brutschy B, Steinhilber D. Häfner AK, et al. Biol Chem. 2011 Dec;392(12):1097-111. doi: 10.1515/BC.2011.200. Biol Chem. 2011. PMID: 22050225
Inhibition of 5-lipoxygenase by U73122 is due to covalent binding to cysteine 416.
Hörnig M, Markoutsa S, Häfner AK, George S, Wisniewska JM, Rödl CB, Hofmann B, Maier T, Karas M, Werz O, Steinhilber D. Hörnig M, et al. Among authors: hafner ak. Biochim Biophys Acta. 2012 Feb;1821(2):279-86. doi: 10.1016/j.bbalip.2011.11.001. Epub 2011 Nov 23. Biochim Biophys Acta. 2012. PMID: 22137889
Electrophilic fatty acid species inhibit 5-lipoxygenase and attenuate sepsis-induced pulmonary inflammation.
Awwad K, Steinbrink SD, Frömel T, Lill N, Isaak J, Häfner AK, Roos J, Hofmann B, Heide H, Geisslinger G, Steinhilber D, Freeman BA, Maier TJ, Fleming I. Awwad K, et al. Among authors: hafner ak. Antioxid Redox Signal. 2014 Jun 10;20(17):2667-80. doi: 10.1089/ars.2013.5473. Epub 2014 Feb 3. Antioxid Redox Signal. 2014. PMID: 24206143 Free PMC article.
Exploring the chemical space of multitarget ligands using aligned self-organizing maps.
Achenbach J, Klingler FM, Blöcher R, Moser D, Häfner AK, Rödl CB, Kretschmer S, Krüger B, Löhr F, Stark H, Hofmann B, Steinhilber D, Proschak E. Achenbach J, et al. Among authors: hafner ak. ACS Med Chem Lett. 2013 Oct 23;4(12):1169-72. doi: 10.1021/ml4002562. eCollection 2013 Dec 12. ACS Med Chem Lett. 2013. PMID: 24900624 Free PMC article.
Lipoxin and resolvin biosynthesis is dependent on 5-lipoxygenase activating protein.
Lehmann C, Homann J, Ball AK, Blöcher R, Kleinschmidt TK, Basavarajappa D, Angioni C, Ferreirós N, Häfner AK, Rådmark O, Proschak E, Haeggström JZ, Geisslinger G, Parnham MJ, Steinhilber D, Kahnt AS. Lehmann C, et al. Among authors: hafner ak. FASEB J. 2015 Dec;29(12):5029-43. doi: 10.1096/fj.15-275487. Epub 2015 Aug 19. FASEB J. 2015. PMID: 26289316
26 results