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PI3Kγ is a molecular switch that controls immune suppression.
Kaneda MM, Messer KS, Ralainirina N, Li H, Leem CJ, Gorjestani S, Woo G, Nguyen AV, Figueiredo CC, Foubert P, Schmid MC, Pink M, Winkler DG, Rausch M, Palombella VJ, Kutok J, McGovern K, Frazer KA, Wu X, Karin M, Sasik R, Cohen EE, Varner JA. Kaneda MM, et al. Among authors: varner ja. Nature. 2016 Nov 17;539(7629):437-442. doi: 10.1038/nature19834. Epub 2016 Sep 19. Nature. 2016. PMID: 27642729 Free PMC article.
Myeloid cell trafficking and tumor angiogenesis.
Schmid MC, Varner JA. Schmid MC, et al. Among authors: varner ja. Cancer Lett. 2007 May 18;250(1):1-8. doi: 10.1016/j.canlet.2006.09.002. Epub 2006 Oct 17. Cancer Lett. 2007. PMID: 17049723 Free PMC article. Review.
Circulating endothelial progenitor cells.
Schmid MC, Varner JA. Schmid MC, et al. Among authors: varner ja. Methods Mol Biol. 2009;467:139-55. doi: 10.1007/978-1-59745-241-0_8. Methods Mol Biol. 2009. PMID: 19301669
Integrin alpha4beta1 signaling is required for lymphangiogenesis and tumor metastasis.
Garmy-Susini B, Avraamides CJ, Schmid MC, Foubert P, Ellies LG, Barnes L, Feral C, Papayannopoulou T, Lowy A, Blair SL, Cheresh D, Ginsberg M, Varner JA. Garmy-Susini B, et al. Among authors: varner ja. Cancer Res. 2010 Apr 15;70(8):3042-51. doi: 10.1158/0008-5472.CAN-09-3761. Epub 2010 Apr 13. Cancer Res. 2010. PMID: 20388801 Free PMC article.
Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3kγ, a single convergent point promoting tumor inflammation and progression.
Schmid MC, Avraamides CJ, Dippold HC, Franco I, Foubert P, Ellies LG, Acevedo LM, Manglicmot JR, Song X, Wrasidlo W, Blair SL, Ginsberg MH, Cheresh DA, Hirsch E, Field SJ, Varner JA. Schmid MC, et al. Among authors: varner ja. Cancer Cell. 2011 Jun 14;19(6):715-27. doi: 10.1016/j.ccr.2011.04.016. Cancer Cell. 2011. PMID: 21665146 Free PMC article.
Integrins in tumor angiogenesis and lymphangiogenesis.
Foubert P, Varner JA. Foubert P, et al. Among authors: varner ja. Methods Mol Biol. 2012;757:471-86. doi: 10.1007/978-1-61779-166-6_27. Methods Mol Biol. 2012. PMID: 21909928 Free PMC article.
80 results