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An assay to measure poly(ADP ribose) glycohydrolase (PARG) activity in cells.
James DI, Durant S, Eckersley K, Fairweather E, Griffiths LA, Hamilton N, Kelly P, O'Connor M, Shea K, Waddell ID, Ogilvie DJ. James DI, et al. Among authors: hamilton n. F1000Res. 2016 Apr 25;5:736. doi: 10.12688/f1000research.8463.2. eCollection 2016. F1000Res. 2016. PMID: 27610220 Free PMC article.
First-in-Class Chemical Probes against Poly(ADP-ribose) Glycohydrolase (PARG) Inhibit DNA Repair with Differential Pharmacology to Olaparib.
James DI, Smith KM, Jordan AM, Fairweather EE, Griffiths LA, Hamilton NS, Hitchin JR, Hutton CP, Jones S, Kelly P, McGonagle AE, Small H, Stowell AI, Tucker J, Waddell ID, Waszkowycz B, Ogilvie DJ. James DI, et al. ACS Chem Biol. 2016 Nov 18;11(11):3179-3190. doi: 10.1021/acschembio.6b00609. Epub 2016 Oct 12. ACS Chem Biol. 2016. PMID: 27689388
Cell-Active Small Molecule Inhibitors of the DNA-Damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sulfonamides.
Waszkowycz B, Smith KM, McGonagle AE, Jordan AM, Acton B, Fairweather EE, Griffiths LA, Hamilton NM, Hamilton NS, Hitchin JR, Hutton CP, James DI, Jones CD, Jones S, Mould DP, Small HF, Stowell AIJ, Tucker JA, Waddell ID, Ogilvie DJ. Waszkowycz B, et al. J Med Chem. 2018 Dec 13;61(23):10767-10792. doi: 10.1021/acs.jmedchem.8b01407. Epub 2018 Nov 19. J Med Chem. 2018. PMID: 30403352
Fluoromethylcyclopropylamine derivatives as potential in vivo toxicophores - A cautionary disclosure.
Acton B, Small HF, Smith KM, McGonagle A, Stowell AIJ, James DI, Hamilton NM, Hamilton N, Hitchin JR, Hutton CP, Waddell ID, Ogilvie DJ, Jordan AM. Acton B, et al. Among authors: hamilton nm, hamilton n. Bioorg Med Chem Lett. 2019 Feb 15;29(4):560-562. doi: 10.1016/j.bmcl.2018.12.066. Epub 2019 Jan 2. Bioorg Med Chem Lett. 2019. PMID: 30616904 Free PMC article.
Novel steroid inhibitors of glucose 6-phosphate dehydrogenase.
Hamilton NM, Dawson M, Fairweather EE, Hamilton NS, Hitchin JR, James DI, Jones SD, Jordan AM, Lyons AJ, Small HF, Thomson GJ, Waddell ID, Ogilvie DJ. Hamilton NM, et al. J Med Chem. 2012 May 10;55(9):4431-45. doi: 10.1021/jm300317k. Epub 2012 Apr 27. J Med Chem. 2012. PMID: 22506561
Toxoflavins and deazaflavins as the first reported selective small molecule inhibitors of tyrosyl-DNA phosphodiesterase II.
Raoof A, Depledge P, Hamilton NM, Hamilton NS, Hitchin JR, Hopkins GV, Jordan AM, Maguire LA, McGonagle AE, Mould DP, Rushbrooke M, Small HF, Smith KM, Thomson GJ, Turlais F, Waddell ID, Waszkowycz B, Watson AJ, Ogilvie DJ. Raoof A, et al. J Med Chem. 2013 Aug 22;56(16):6352-70. doi: 10.1021/jm400568p. Epub 2013 Jul 31. J Med Chem. 2013. PMID: 23859074
Discovery and Optimization of Allosteric Inhibitors of Mutant Isocitrate Dehydrogenase 1 (R132H IDH1) Displaying Activity in Human Acute Myeloid Leukemia Cells.
Jones S, Ahmet J, Ayton K, Ball M, Cockerill M, Fairweather E, Hamilton N, Harper P, Hitchin J, Jordan A, Levy C, Lopez R, McKenzie E, Packer M, Plant D, Simpson I, Simpson P, Sinclair I, Somervaille TC, Small H, Spencer GJ, Thomson G, Tonge M, Waddell I, Walsh J, Waszkowycz B, Wigglesworth M, Wiseman DH, Ogilvie D. Jones S, et al. Among authors: hamilton n. J Med Chem. 2016 Dec 22;59(24):11120-11137. doi: 10.1021/acs.jmedchem.6b01320. Epub 2016 Dec 5. J Med Chem. 2016. PMID: 28002956
The spectrum of systemic sclerosis-associated pulmonary hypertension: Insights from the ASPIRE registry.
Smith H, Thompson AAR, Akil M, Alabed S, Charalampopoulos A, Dwivedi K, Elliot CA, Hameed A, Haque A, Hamilton N, Hill C, Hurdman J, Kilding R, Kuet KP, Rajaram S, Rothman AMK, Swift AJ, Wild JM, Kiely DG, Condliffe R. Smith H, et al. Among authors: hamilton n. J Heart Lung Transplant. 2024 Oct;43(10):1629-1639. doi: 10.1016/j.healun.2024.06.007. J Heart Lung Transplant. 2024. PMID: 39260921 Free article.
553 results