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HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response.
Rotblat B, Southwell AL, Ehrnhoefer DE, Skotte NH, Metzler M, Franciosi S, Leprivier G, Somasekharan SP, Barokas A, Deng Y, Tang T, Mathers J, Cetinbas N, Daugaard M, Kwok B, Li L, Carnie CJ, Fink D, Nitsch R, Galpin JD, Ahern CA, Melino G, Penninger JM, Hayden MR, Sorensen PH. Rotblat B, et al. Among authors: sorensen ph. Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3032-7. doi: 10.1073/pnas.1314421111. Epub 2014 Feb 10. Proc Natl Acad Sci U S A. 2014. PMID: 24516159 Free PMC article.
Loss of the tumor suppressor Hace1 leads to ROS-dependent glutamine addiction.
Cetinbas N, Daugaard M, Mullen AR, Hajee S, Rotblat B, Lopez A, Li A, DeBerardinis RJ, Sorensen PH. Cetinbas N, et al. Among authors: sorensen ph. Oncogene. 2015 Jul 23;34(30):4005-10. doi: 10.1038/onc.2014.316. Epub 2014 Oct 6. Oncogene. 2015. PMID: 25284589 Free PMC article.
Translational Activation of HIF1α by YB-1 Promotes Sarcoma Metastasis.
El-Naggar AM, Veinotte CJ, Cheng H, Grunewald TG, Negri GL, Somasekharan SP, Corkery DP, Tirode F, Mathers J, Khan D, Kyle AH, Baker JH, LePard NE, McKinney S, Hajee S, Bosiljcic M, Leprivier G, Tognon CE, Minchinton AI, Bennewith KL, Delattre O, Wang Y, Dellaire G, Berman JN, Sorensen PH. El-Naggar AM, et al. Among authors: sorensen ph. Cancer Cell. 2015 May 11;27(5):682-97. doi: 10.1016/j.ccell.2015.04.003. Cancer Cell. 2015. PMID: 25965573 Free article.
eEF2K inhibition blocks Aβ42 neurotoxicity by promoting an NRF2 antioxidant response.
Jan A, Jansonius B, Delaidelli A, Somasekharan SP, Bhanshali F, Vandal M, Negri GL, Moerman D, MacKenzie I, Calon F, Hayden MR, Taubert S, Sorensen PH. Jan A, et al. Among authors: sorensen ph. Acta Neuropathol. 2017 Jan;133(1):101-119. doi: 10.1007/s00401-016-1634-1. Epub 2016 Oct 17. Acta Neuropathol. 2017. PMID: 27752775
Insulin-like growth factor 1 receptor stabilizes the ETV6-NTRK3 chimeric oncoprotein by blocking its KPC1/Rnf123-mediated proteasomal degradation.
Tognon CE, Rafn B, Cetinbas NM, Kamura T, Trigo G, Rotblat B, Okumura F, Matsumoto M, Chow C, Davare M, Pollak M, Mayor T, Sorensen PH. Tognon CE, et al. Among authors: sorensen ph. J Biol Chem. 2018 Aug 10;293(32):12502-12515. doi: 10.1074/jbc.RA117.000321. Epub 2018 Jun 14. J Biol Chem. 2018. PMID: 29903916 Free PMC article.
237 results