Maechler P - Search Results

1

Integrative Genomics Outlines a Biphasic Glucose Response and a ChREBP-RORγ Axis Regulating Proliferation in β Cells.

Schmidt SF, Madsen JG, Frafjord KØ, Poulsen Ll, Salö S, Boergesen M, Loft A, Larsen BD, Madsen MS, Holst JJ, Maechler P, Dalgaard LT, Mandrup S. Schmidt SF, et al. Among authors: maechler p. Cell Rep. 2016 Aug 30;16(9):2359-72. doi: 10.1016/j.celrep.2016.07.063. Epub 2016 Aug 18. Cell Rep. 2016. PMID: 27545881 Free article.

2

Peroxisome proliferator-activated receptor alpha (PPARalpha) potentiates, whereas PPARgamma attenuates, glucose-stimulated insulin secretion in pancreatic beta-cells.

Ravnskjaer K, Boergesen M, Rubi B, Larsen JK, Nielsen T, Fridriksson J, Maechler P, Mandrup S. Ravnskjaer K, et al. Among authors: maechler p. Endocrinology. 2005 Aug;146(8):3266-76. doi: 10.1210/en.2004-1430. Epub 2005 May 5. Endocrinology. 2005. PMID: 15878969

3

Deletion of glutamate dehydrogenase in beta-cells abolishes part of the insulin secretory response not required for glucose homeostasis.

Carobbio S, Frigerio F, Rubi B, Vetterli L, Bloksgaard M, Gjinovci A, Pournourmohammadi S, Herrera PL, Reith W, Mandrup S, Maechler P. Carobbio S, et al. Among authors: maechler p. J Biol Chem. 2009 Jan 9;284(2):921-9. doi: 10.1074/jbc.M806295200. Epub 2008 Nov 17. J Biol Chem. 2009. PMID: 19015267 Free article.

4

Peroxisome proliferator-activated receptor alpha (PPARalpha) protects against oleate-induced INS-1E beta cell dysfunction by preserving carbohydrate metabolism.

Frigerio F, Brun T, Bartley C, Usardi A, Bosco D, Ravnskjaer K, Mandrup S, Maechler P. Frigerio F, et al. Among authors: maechler p. Diabetologia. 2010 Feb;53(2):331-40. doi: 10.1007/s00125-009-1590-6. Epub 2009 Nov 12. Diabetologia. 2010. PMID: 19908022

5

PPARdelta is a fatty acid sensor that enhances mitochondrial oxidation in insulin-secreting cells and protects against fatty acid-induced dysfunction.

Ravnskjaer K, Frigerio F, Boergesen M, Nielsen T, Maechler P, Mandrup S. Ravnskjaer K, et al. Among authors: maechler p. J Lipid Res. 2010 Jun;51(6):1370-9. doi: 10.1194/jlr.M001123. Epub 2009 Nov 30. J Lipid Res. 2010. PMID: 19965574 Free PMC article.

6

ChREBP mediates glucose repression of peroxisome proliferator-activated receptor alpha expression in pancreatic beta-cells.

Boergesen M, Poulsen Ll, Schmidt SF, Frigerio F, Maechler P, Mandrup S. Boergesen M, et al. Among authors: maechler p. J Biol Chem. 2011 Apr 15;286(15):13214-25. doi: 10.1074/jbc.M110.215467. Epub 2011 Jan 31. J Biol Chem. 2011. PMID: 21282101 Free PMC article.

7

Mitochondrial dysfunction in pancreatic β cells.

Supale S, Li N, Brun T, Maechler P. Supale S, et al. Among authors: maechler p. Trends Endocrinol Metab. 2012 Sep;23(9):477-87. doi: 10.1016/j.tem.2012.06.002. Epub 2012 Jul 4. Trends Endocrinol Metab. 2012. PMID: 22766318 Review.

8

GDH-Dependent Glutamate Oxidation in the Brain Dictates Peripheral Energy Substrate Distribution.

Karaca M, Frigerio F, Migrenne S, Martin-Levilain J, Skytt DM, Pajecka K, Martin-del-Rio R, Gruetter R, Tamarit-Rodriguez J, Waagepetersen HS, Magnan C, Maechler P. Karaca M, et al. Among authors: maechler p. Cell Rep. 2015 Oct 13;13(2):365-75. doi: 10.1016/j.celrep.2015.09.003. Epub 2015 Oct 1. Cell Rep. 2015. PMID: 26440896 Free article.

9

Palmitate and oleate modify membrane fluidity and kinase activities of INS-1E β-cells alongside altered metabolism-secretion coupling.

Oberhauser L, Granziera S, Colom A, Goujon A, Lavallard V, Matile S, Roux A, Brun T, Maechler P. Oberhauser L, et al. Among authors: maechler p. Biochim Biophys Acta Mol Cell Res. 2020 Feb;1867(2):118619. doi: 10.1016/j.bbamcr.2019.118619. Epub 2019 Dec 7. Biochim Biophys Acta Mol Cell Res. 2020. PMID: 31816355 Free article.

10

AMPK Profiling in Rodent and Human Pancreatic Beta-Cells under Nutrient-Rich Metabolic Stress.

Brun T, Jiménez-Sánchez C, Madsen JGS, Hadadi N, Duhamel D, Bartley C, Oberhauser L, Trajkovski M, Mandrup S, Maechler P. Brun T, et al. Among authors: maechler p. Int J Mol Sci. 2020 Jun 1;21(11):3982. doi: 10.3390/ijms21113982. Int J Mol Sci. 2020. PMID: 32492936 Free PMC article.

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